糖尿病眼表病变的研究进展  

Research progress in diabetic ocular surface lesions

作　　者：向英 李霞 宋秀胜 Xiang Ying;Li Xia;Song Xiusheng(Ophthalmic Center of the Central Hospital of Enshi Autonomous Prefecture,Enshi Clinical College of Wuhan University,Enshi Prefectural Hospital Affiliated to Hubei Minzu University,Enshi 445000,Hubei Province,China;Medical School of Hubei Minzu University,Enshi 445000,Hubei Province,China)

机构地区：[1]恩施自治州中心医院湖北民族大学附属恩施州中心医院武汉大学恩施临床学院眼科中心,湖北恩施445000 [2]湖北民族大学医学院,湖北恩施445000

出　　处：《国际眼科纵览》2020年第4期245-249,共5页International Review of Ophthalmology

摘　　要：糖尿病患病率呈逐年上升趋势,其并发症多且复杂,致残致死率高。与糖尿病视网膜病变相比,糖尿病眼表病变易被眼科医生忽略。糖尿病眼表病变发生率高,角膜病变及泪膜的改变是其主要表现,包括角膜上皮基底下神经密度降低、角膜上皮基底膜增厚、角膜敏感度降低、泪膜稳定性下降和泪液分泌减少等。但目前糖尿病眼表病变的诊断标准尚未统一。其致病关键因素是高糖所致的氧化应激反应,这为糖尿病眼表疾病的病因治疗提供了研究方向。The prevalence of diabetes mellitus has been increased year by year,and its complications and mortality is a serious health problems in the world.Compared with diabetic retinopathy,the diabetic ocular surface complications were insufficiently studied by ophthalmologists.Keratopathy and tear film changes of diabetes mellitus patients are the main complications with a high incidence.Keratopathy mainly presents as cornea neuropathy and epithelial disease.However,the stardard of diabetic ocular surface lesions is not established yet.Reactive oxidative stress caused by high levels of glucose is key pathogenic factor of keratopathy,so it can provide a research clue for the treatment of ocular surface complications for diabetes mellitus.

关 键 词：眼表 糖尿病 角膜神经 角膜敏感性 泪膜 

分 类 号：R587.2[医药卫生—内分泌] R771.3[医药卫生—内科学]