应用不同剂量比阿培南治疗重症肺炎的研究  

Effect and safety analysis of different dosage of biapenem in the treatment of severe pneumonia

作　　者：暨永亮 林捷[1] 张怡[1] JI Yong-liang;LIN Jie;ZHANG Yi(ICU,Fujian provincial government hospital,Fuzhou City,Fujian Province,350000,China)

机构地区：[1]福建省级机关医院急危重症科,福建福州350000

出　　处：《蛇志》2020年第3期315-316,322,共3页Journal of Snake

摘　　要：目的探讨不同剂量比阿培南治疗重症肺炎的效果及安全性。方法选择2016年1月~2019年10月在我院治疗的120例重症肺炎患者为研究对象,按随机数字表法分为对照组和观察组。对照组61例给予常规剂量比阿培南治疗,观察组59例使用高剂量比阿培南静脉滴注治疗,观察比较两组患者的治疗效果、血气分析指标及药物不良反应情况。结果观察组的治疗总有效率优于对照组,组间比较差异有统计学意义(P<0.05)。两组患者的血气分析指标比较,治疗前两组患者的pH值、PaCO2、SaO2、PaO2/FiO2、PaO2比较,差异无统计学意义(均P>0.05);治疗后,观察组的SaO2、PaO2/FiO2、PaO2指标水平均高于对照组,组间比较差异有统计学意义(均P<0.05)。两组患者的不良反应比较,观察组的不良反应发生率为8.0%,对照组为5.0%,两组比较差异无统计学意义(P>0.05)。结论大剂量比阿培南应用于重症肺炎患者的治疗效果确切,可有效改善患者血气指标,且具有较高的安全性,值得临床应用。Objective To analyze and study the efficacy and safety of different doses of biapenem in the treatment of severe pneumonia.Methods 120 patients with severe pneumonia admitted to our hospital from January 2016 to October 2019 were randomly divided into two groups,the control group and the observation group.There were 61 cases in the control group and 59 cases in the observation group.The conventional dose of biapenem was applied to the treatment of patients in the control group,and the treatment mode of patients in the observation group was intravenous drip of high-dose biapenem.After treatment,the therapeutic effect,blood gas analysis index and adverse drug reactions were compared between the two groups.Results After the treatment,the total effective rate of the observation group was higher than that of the control group,and there was a significant difference between the two groups(P<0.05).In terms of blood gas analysis indexes,there were no significant difference in pH value,PaCO2,SaO2,PaO2/FiO2 and PaO2 between the two groups before treatment(P>0.05 for each).After treatment,SaO2,PaO2/FiO2 and PaO2 in the observation group were higher than those in the control group,and there were a significant difference between the two groups(P<0.05 for each).The incidence of adverse reactions in the observation group was 8.0%,control group was 5.0%,there was no significant difference between two groups(P>0.05).Conclusion the effect of large dose of biapenem in the treatment of patients with severe pneumonia is affirmative,which can effectively improve the blood gas index as well as high safety,which is worthy of clinical adoption.

关 键 词：比阿培南 重症肺炎 剂量 效果 安全性 

分 类 号：R563.1[医药卫生—呼吸系统]