不对称亲核催化合成手性芳基烯丙基醚类化合物  

Asymmetric Synthesis of Chiral Aryl Allyl Ethers by Nucleophilic Catalysis

作　　者：赵帅[1] 陈湘香[1] 金雷[1] 陈至立 陈新[1] ZHAO Shuai;CHEN Xiangxiang;JIN Lei;CHEN Zhili;CHEN Xin(School of Pharmaceutical Engineering&Life Sciences,Changzhou University,Changzhou 213164,China)

机构地区：[1]常州大学制药与生命科学学院,江苏常州213164

出　　处：《常州大学学报（自然科学版）》2020年第5期27-34,共8页Journal of Changzhou University：Natural Science Edition

基　　金：国家自然科学基金资助项目(21602018)。

摘　　要：手性芳基烯丙基醚类化合物是一类重要的结构骨架,其广泛存在于天然产物和药物活性分子结构中。以设计合成的MBH(Morita-Baylis-Hillman)碳酸苯酯作为反应底物,其在亲核手性催化剂作用下脱去一分子CO 2,生成了一系列含有各种取代基的手性的芳基烯丙基醚化合物。产率高达95%,对映选择性高达90%。产物结构经1 H NMR和13 C NMR鉴定正确。Chiral aryl allyl ethers are important substructure which can be found in a lot of natural products and bioactive molecules.A series of substituted chiral aryl allyl ethers were successfully synthesized from the newly designed MBH carbonates by releasing a molecule of CO 2 under nucleophilic catalysis.The yields are up to 95%and the enantioselectivities are up to 90%.The structure of products was determined by 1 H NMR and 13 C NMR.

关 键 词：亲核催化 脱CO 2 手性芳基烯丙基醚 

分 类 号：O625.3[理学—有机化学]