注射用甘露聚糖肽致速发型过敏性休克严重不良反应分析  

Severe Adverse Drug Reaction of Acute Anaphylactic Shock Induced by Mannatide

作　　者：曹原[1] 王雪[1] 孙甜甜 高婕[1] CAO Yuan;WANG Xue;SUN Tiantian;GAO Jie(Department of Pharmacy,Zibo Central Hospital,Zibo Shandong 255036,China;Department of Oncology,Zibo Central Hospital,Zibo Shandong 255036,China)

机构地区：[1]淄博市中心医院药学部,山东淄博255036 [2]淄博市中心医院肿瘤科,山东淄博255036

出　　处：《中国药物警戒》2020年第10期707-709,共3页Chinese Journal of Pharmacovigilance

基　　金：淄博市重点研发计划(2018kj010091)。

摘　　要：目的探索甘露聚糖肽致速发型过敏性休克严重不良反应的处理方法和经验。方法甘露聚糖肽常用于治疗免疫功能低下导致的各种疾病,对2例使用该药物致速发型过敏性休克严重不良反应的实例进行分析。结果 2位患者均在滴注注射用甘露聚糖肽约10 min内发生过敏性休克不良反应。停用甘露聚糖肽、使用抗过敏药物、吸氧等对症治疗后,患者症状缓解。结论临床使用甘露聚糖肽时,应在用药前仔细询问患者过敏史和病史,用药期间对患者进行严密监护。皮肤试验和给药前使用抗过敏药物可对不良反应的发生进行预防。Objective To explore the methods of managing severe adverse drug reactions of acute anaphylactic shock induced by mannatide.Methods Two cases of severe adverse drug reactions of acute anaphylactic shock induced by mannatide,a drug often used for diseases caused by hypoimmunity,were analyzed.Results Both patients suffered from anaphylactic shock within about 10 minutes of intravenous drip of mannatide.The patients’symptoms were ameliorated after such symptomatic treatments as the withdrawal of mannatide,use of anti-allergic drugs and oxygen inhalation.Conclusion Clinicians are to learn about the allergic history and medical history of patients before the medication with mannatide injection.Patients should be closely monitored during medication.The skin test and use of anti-allergic drugs before administration could help prevent adverse drug reactions.

关 键 词：甘露聚糖肽 过敏 不良反应 皮试 

分 类 号：R994.11[医药卫生—毒理学]