温阳健脾解毒方治疗慢性淋巴细胞性甲状腺炎临床观察  

Efficacy observation of Wenyang Jianpi Jiedu recipe on chronic lymphocytic thyroiditis

作　　者：张恒耀 董朝侠 董慧杰[1] 田强[1] 邓自辉[1] 魏颜宁 党毓起[1] ZHANG Heng-yao;DONG Chao-xia;DONG Hui-jie(Yinchuan Hospital of Traditional Chinese Medicine Affiliated to Ningxia Medical University,Yinchuan 750001,China)

机构地区：[1]宁夏医科大学附属银川市中医医院,银川750001

出　　处：《山西中医》2020年第10期32-34,37,共4页Shanxi Journal of Traditional Chinese Medicine

基　　金：宁夏医科大学科学研究基金资助项目(编号:XM2018050);宁夏青年科技人才托举工程资助项目(编号:TJGC2019097)。

摘　　要：目的:观察温阳健脾解毒方治疗脾肾阳虚型慢性淋巴细胞性甲状腺炎的有效性和安全性。方法:筛选符合纳入标准的患者71例,随机分为治疗组37例和对照组34例,对照组予基础治疗(生活方式干预和口服左甲状腺素钠片),治疗组予基础治疗联合口服温阳健脾解毒方,共治疗12周,记录两组患者中医证候积分、甲状腺功能、甲状腺抗体滴度及相关安全性指标的变化,并进行统计学分析。结果:(1)研究共完成63例可评价样本,治疗组32例,对照组31例;(2)治疗后治疗组TSH、FT3、TPOAb、TGAb水平均有明显改善(P<0.05),且FT3、TGAb指标改善优于对照组(P<0.05);(3)两组中医证候积分较基线均明显降低,且治疗组证候疗效优于对照组(P<0.01);(4)两组患者未发生药物相关不良事件。结论:温阳健脾解毒方配合西药治疗能够有效降低慢性淋巴细胞性甲状腺炎患者甲状腺自身免疫抗体滴度,显著改善中医证候。Objective:To observe the effectiveness and safety of Wenyang Jianpi Jiedu recipe on chronic lymphocytic thyroiditis of spleen and kidney yang deficiency syndrome.Methods:71 cases of selected and researched patients met the inclusion criteria were randomly divided into treatment group(37 cases)and control group(34 cases).The control group received basic treatment(lifestyle intervention and oral levothyroxine sodium tablets),while the treatment group was treated with oral Wenyang Jianpi Jiedu recipe on the basis of basic treatment,in total for 12 weeks.The changes of TCM syndrome score,thyroid function,thyroid antibody titer and safety-related indexes of patients were recored in two groups,and statistically analyzed.Results:(1)A total of 63 evaluable samples were completed in the research,including 32 samples in treatment group and 31 samples in control group.(2)After treatment,the levels of TSH,FT3,TPOAb and TGAb in the treatment group improved significantly(P﹤0.05),and the improvement of FT3 and TGAb index was better than that inthe control group(P﹤0.05).(3)The scores of TCM syndromes in both groups were significantly decreased compared with the baseline,and the therapeutic effect of syndromes in treatment group was better than that in control group(P﹤0.01).(4)There were no drug-related adverse events in the patients of both groups.Conclusion:Wenyang Jianpi Jiedu recipe can effectively reduce the thyroid autoimmune antibody titer of patients with chronic lymphocytic thyroiditis,and significantly improve TCM syndromes.

关 键 词：慢性淋巴细胞性甲状腺炎 温阳健脾解毒 中西医结合疗法 

分 类 号：R581.4[医药卫生—内分泌]