光动力治疗胆管恶性梗阻的初步临床疗效  

Preliminary clinical effect of photodynamic therapy for malignant biliary obstruction

作　　者：庄东海 张洪战 孙永梅 张锎 张明 ZHUANG Dong-hai;ZHANG Hong-zhan;SUN Yong-mei;ZHANG Kai;ZHANG Ming(Department of Hepatobiliary Surgery,Shandong Provincial Third Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250031,China)

机构地区：[1]山东省立第三医院肝胆外科,山东济南250031

出　　处：《中国现代普通外科进展》2020年第9期708-712,共5页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:初步评价光动力治疗胆管恶性梗阻的临床疗效。方法:选取12例胆管恶性梗阻患者,常规实施ERCP后,行肿瘤光动力治疗,然后留置胆道支架,观察术后恢复情况。结果:12例患者均成功接收光动力治疗并置入胆道支架(塑料支架9例,金属支架3例),技术成功率100%。临床成功率91.6%(11/12),1例患者术后7天总胆红素下降﹤50%。1例术后并发胰腺炎,保守治疗后好转出院。1个月内支架通畅率100%,3个月内支架通畅率100%。PDT治疗后3个月内镜随访,有效率100%。结论:光动力治疗胆管恶性梗阻是安全、有效的,有待通过大样本、多中心的临床研究进一步探讨。Objective:Preliminary evaluation of photodynamic therapy for malignant biliary obstruction.Methods:A total of 12 pantients with malignant biliary obstruction were selected for this study.After ERCP diagnosis,photodynamic therapy was performed,and then biliary stent was retained to observe the postoperative recovery.Results:Photodynamic therapy and stent placement were successful in all 12 patients(Plastic stent 9 cases,metal stent 3 cases),technology success rate was 100%.Clinical success rate was 91.6%(11/12),the total bilirubin decreased less than 50%7 days after operation in one patient.One case of postoperative pancreatitis was controlled and discharged after conservative treatment.The patency rate of stent was 100%in 1 month and 100%in 3 months.3 months after PDT,the effective rate was 100%.Conclusion:Photodynamic therapy for malignant biliary obstruction is safe and effective,which needs to be further explored through large sample and multi center clinical research.

关 键 词：光动力 胆管恶性梗阻 经内镜逆行胰胆管造影术 

分 类 号：R657.4[医药卫生—外科学]