妊娠期糖尿病患者持续皮下输注胰岛素的安全有效性  

Effectiveness and safety of continuous subcutaneous insulin infusion in the treatment of gestational diabetes patients

作　　者：赵萍[1] 张黎[2] ZHAO Ping;ZHANG Li(Department of Respiratory Endocrinology,Sanyuan County Hospital in Xianyang City of Shaanxi Province,Xianyang,Shaanxi,715800;Department of Obstetrics,Sanyuan County Hospital in Xianyang City of Shaanxi Province,Xianyang,Shaanxi,715800)

机构地区：[1]陕西省咸阳市三原县医院呼吸内分泌科,陕西咸阳715800 [2]陕西省咸阳市三原县医院产科,陕西咸阳715800

出　　处：《实用临床医药杂志》2020年第15期61-64,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨妊娠期糖尿病治疗中持续皮下输注胰岛素的有效性与安全性。方法将妊娠期糖尿病患者80例分为对照组和研究组。对照组采用胰岛素多次皮下注射疗法,研究组采用持续皮下输注胰岛素疗法。比较2组疗效及安全性。结果研究组胰岛素用量、血糖漂移度显著小于对照组,血糖达标时间显著早于对照组(P<0.05);治疗前,2组空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbAlc)及血清同型半胱氨酸(Hcy)、血清胱抑素C(Cys-C)指标水平比较,差异无统计学意义(P>0.05);治疗后,研究组血糖指标及血清指标水平均显著低于对照组(P<0.05);研究组早产、剖宫产、妊高征、羊水过多、新生儿窒息等不良事件发生率显著低于对照组(P<0.05)。结论妊娠期糖尿病患者采用持续皮下输注胰岛素法治疗的效果显著,且安全性较高。Objective To investigate the effectiveness and safety of continuous subcutaneous insulin infusion in the treatment of gestational diabetes.Methods A total of 80 patients with gestational diabetes were divided into control group and study group.The control group was treated with multiple subcutaneous injections of insulin,while the study group was treated with continuous subcutaneous infusion of insulin.The efficacy and safety of the two groups were compared.Results The insulin dosage and blood glucose drift of the study group were smaller than those of the control group,and the time to reach the standard value of blood glucose was earlier than that in the control group,and the differences were significant(P<0.05).The levels of fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG),hemoglobin(HbAlc),serum homocysteine(Hcy),and serum cystatin C(Cys-C)showed no significant differences before treatment(P>0.05).After treatment,the blood glucose indexes and serum indexes levels of the study group were significantly low than those in the control group(P<0.05);the incidence of adverse events such as premature delivery,cesarean section,pregnancy-induced hypertension,polyhydramnios,and neonatal asphyxia in the study group was lower than that in the control group(P<0.05).Conclusion Continuous subcutaneous insulin infusion therapy in patients with gestational diabetes has significant results and higher safety.

关 键 词：妊娠期糖尿病 多次皮下注射 持续皮下输注 胰岛素 血糖指标 安全性 

分 类 号：R714.25[医药卫生—妇产科学]