腺苷三磷酸结合盒转运蛋白家族成员乳腺癌耐药蛋白基因多态性对药代动力学影响的研究现状  

Research status of the effect of adenosine triphosphate binding cassette super family G member 2 gene polymorphism on pharmacokinetics

作　　者：吴茂锋 刘畅[1] 苏时光 贾晶晶 方翼 WU Mao-feng;LIU Chang;SU Shi-guang;JIA Jing-jing;FANG Yi(Phase I Clinical Research Unit,The Sixth Affiliated Hospital of Guangzhou Medical University/Qingyuan People’s Hospital,Qingyuan 511518,Guangdong Province,China;Department of Pharmacy,Peking University People’s Hospital,Beijing 100044,China)

机构地区：[1]广州医科大学附属第六医院/清远市人民医院药物Ⅰ期临床研究室,广东清远511518 [2]北京大学人民医院药剂科,北京100044

出　　处：《中国临床药理学杂志》2020年第17期2732-2736,共5页The Chinese Journal of Clinical Pharmacology

基　　金：清远市科技计划基金资助项目(DZXQY002);清远市人民医院医学科研基金资助项目(20190208)。

摘　　要：腺苷三磷酸结合盒转运蛋白家族成员乳腺癌耐药蛋白(ABCG2)参与多种药物的吸收、分布和消除,是涉及药物肠道吸收或渗透最重要的外排转运蛋白之一,具有多功能外排泵的作用。ABCG2基因单核苷酸多态性与多种药物的药代动力学相关。本文就ABCG2基因单核苷酸多态性与药物药代动力学关系的最新研究进行综述。Adenosine triphosphate binding cassette superfamily G member 2(ABCG2)has the function of multifunctional efflux pump.It is one of the most important efflux transporters involved in intestinal absorption or permeation of drugs and relevant to the absorption,distribution and elimination of many drugs.Single nucleotide polymorphism of the ABCG2 gene is related to the pharmacokinetics of many drugs.This paper reviews the latest research on the relationship between single nucleotide polymorphism of the ABCG2 gene and pharmacokinetics.

关 键 词：腺苷三磷酸结合盒转运蛋白家族成员乳腺癌耐药蛋白 基因多态性 药代动力学 

分 类 号：R97[医药卫生—药品]