补肺活血胶囊对矽肺患者小气道功能损伤的影响  

Effect of Bufei Huoxue Capsule on silicosis patients with small airway function disability

作　　者：贺今 景华[1] 刘燕[1] 崔萍[1] 李召海 HE Jin;JING Hua;LIU Yan;CUI Ping;LI Zhao-hai(Shandong Academy of Occupational Health and Occupational Medicine,Occupational Pulmonary Disease Department of Shandong First Medical University(Shandong Academy of Medical Sciences),Jinan Shandong,250002,China)

机构地区：[1]山东省职业卫生与职业病防治研究院,山东第一医科大学(山东省医学科学院)职业肺病科,山东济南250002

出　　处：《职业与健康》2020年第15期2032-2035,共4页Occupation and Health

基　　金：山东省医学科学院医药卫生科技创新工程(鲁财教(2016)45号)。

摘　　要：目的观察补肺活血胶囊联合汉防己甲素片治疗矽肺患者合并小气道功能损伤的疗效。方法选择2019年3月山东省职业卫生与职业病防治研究院不同期别(壹期~叁期)的矽肺患者共40例为研究对象,按照随机数字表法分为对照组和观察组各20例。观察组(壹期5例、贰期10例、叁期5例)采用补肺活血胶囊联合汉防己甲素片治疗,在常规汉防己甲素片60 mg 3次/日抗矽治疗基础上加用补肺活血胶囊1.4 g 3次/日;对照组(壹期5例、贰期10例、叁期5例)单纯用汉防己甲素片60 mg 3次/日抗矽治疗。用药3个月后,比较2组治疗前后症状评估、改良的英国医学研究委员会呼吸困难量表(m MRC)呼吸功能评分、肺功能、部分呼出气一氧化氮浓度(FeNO)。结果治疗后,观察组mMRC评分明显低于对照组(P<0.01);观察组肺功能的小气道功能指标25%~75%用力肺活量时用力呼气流量占预计值的百分比明显高于治疗前及治疗后对照组(P<0.05)。观察组FeNO明显低于治疗前及治疗后对照组(P<0.01)。结论补肺活血胶囊具有明显减轻矽肺患者喘息、胸闷及呼吸困难症状及改善小气道功能损伤的作用,值得临床推广应用。Objective To observe the treatment effect of Bufei Huoxue Capsule combined with Tetrandrine Tablets on silicosis pneumoconiosis patients with small airway function disability. Methods 40 silicosis patients(Ⅰ, Ⅱ, Ⅲ stages) from the Shandong academy of occupational health and occupational medicine in March 2019 were enrolled in the study. All patients were divided into the control group(n=20) and observation group(n=20) according to random number table method. The observation group(5 cases of stageⅠ, 10 cases of stageⅡ, 5 cases of stage Ⅲ) were treated with Bufei Huoxue Capsule(1.4 g tid) combined Tetrandrine Tables(60 mg tid). The control group(5 cases of stageⅠ, 10 cases of stageⅡ, 5 cases of stage Ⅲ) were orally treated with Tetrandrine Tables(60 mg tid) only. After 3-month treatment, the symptom evaluation, respiratory function score by modified Medical Research Council scale(mMRC), pulmonary function, and fractional exhaled Nitric Oxide(FeNO) of two groups were compared before and after treatment. Results After treatment, the mMRC score of the observation group was significantly lower than that of the control group(P<0.01). The small airway function index, that is the percentage of forced expiratory flow to predicted value at 25%-75% forced vital capacity, in the observation group was significantly higher than that before treatment, and that in the control group after treatment(P<0.05). FeNO in the observation group was significantly lower than that before treatment, and that of the control group(P<0.01). Conclusion Bufei Huoxue Capsule can significantly reduce the symptoms of wheezing, chest tightness and dyspnea in silicosis patients and improve the small airway function disability, which is worthy of clinical application and promotion.

关 键 词：补肺活血胶囊 矽肺 小气道功能损伤 

分 类 号：R135.2[医药卫生—劳动卫生]