阿奇霉素辅助治疗小儿毛细支气管炎的效果分析  

Analysis of the effect of azithromycin in the adjuvant treatment of bronc hiolitis in children

作　　者：刘从进 Liu Congjin(Jiangsu Huai'an Maternal and Child Health Hospital,Huai'an 223002,China)

机构地区：[1]江苏省淮安市妇幼保健院,江苏淮安223002

出　　处：《当代医药论丛》2020年第17期170-171,共2页

摘　　要：目的:探讨用阿奇霉素辅助治疗小儿毛细支气管炎的效果。方法:选取2016年10月至2019年10月江苏省淮安市妇幼保健院儿科接诊的毛细支气管炎患儿165例,按随机数表法将其分为阿奇霉素组(82例)和常规组(83例)。对常规组患儿进行常规治疗。在此基础上,为阿奇霉素组患儿应用阿奇霉素进行辅助治疗。然后比较两组患儿咳嗽症状缓解的时间、喘息症状缓解的时间、住院的时间及血清肿瘤坏死因子α(TNF-α)、白细胞介素8(IL-8)、干扰素γ(IFN-γ)的水平。结果:与常规组患儿相比,治疗后阿奇霉素组患儿咳嗽症状缓解的时间、喘息症状缓解的时间、住院的时间均较短,其血清TNF-α、IL-8、IFN-γ的水平均较低,P<0.05。结论:用阿奇霉素辅助治疗小儿毛细支气管炎能够快速缓解患儿的临床症状,降低其血清炎症因子的水平,促进其康复。Objective:To investigate the efficacy of azithromycin in the treatment of bronchiolitis in children.Methods:165 cases of bronchiolitis children admitted to the pediatrics department of Huai‘an Maternal and Child Health Hospital from October 2016 to October 2019 were selected and divided into azithromycin group(82 cases)and conventional group(83 cases)according to the random number table method.The children in the routine group received routine treatment.On this basis,azithromycin was used as adjuvant therapy for children in azithromycin group.The duration of relief of cough symptoms,remission of wheezing symptoms,length of hospital stay,and serum levels of tumor necrosis factor(TNF-α),interleukin 8(IL-8),and interferon(IFN-γ)were compared between the two groups.Results:Compared with the conventional group,the relieving time of cough symptom,wheezing symptom and hospitalization time in the azithromycin group were all shorter after treatment,and the serum levels of TNF-α,IL-8 and IFN-γwere all lower,P<0.05.Conclusion:Azithromycin in the adjuvant treatment of bronchiolitis in children can quickly alleviate the clinical symptoms of children,reduce the level of serum inflammatory factors,promote their rehabil itation.

关 键 词：阿奇霉素 小儿毛细支气管炎 炎症因子 

分 类 号：R72[医药卫生—儿科]