胎盘多肽注射液对术后患者的真实世界研究  

A real-world study of placental polypeptide injection on postoperative patients

作　　者：欧银燕 陈文秀 梁辉锐 刘晓琦[3] OU Yinyan;CHEN Wenxiu;LIANG Huirui;LIU Xiaoqi(Clinical Pharmacy Group,Pharmacy Department,Luoding People's Hospital,Guangdong,Luoding 527200,China;Information Section,Luoding People's Hospital,Guangdong,Luoding 527200,China;Pharmacy Department,Guangdong Provincial People's Hospital,Guangdong,Guangzhou 510000,China)

机构地区：[1]广东省罗定市人民医院药学部临床药学组,广东罗定527200 [2]广东省罗定市人民医院信息科,广东罗定527200 [3]广东省人民医院药学部,广东广州510000

出　　处：《中国医药科学》2020年第16期158-161,共4页China Medicine And Pharmacy

基　　金：广东省云浮市医药卫生科研立项课题(2017B45)。

摘　　要：目的了解胎盘多肽注射液在术后患者的真实使用情况,为临床合理用药提供参考。方法采用HIS系统选取我院2016年1月~2019年12月术后使用胎盘多肽注射液的2153例住院患者及同期手术术后未使用该药的32 520例患者,从用药人群、溶媒种类、用法用量、用药疗程、切口愈合情况和不良反应等方面进行统计分析。结果用药患者的年龄集中分布在18~44岁,男女比例为1∶1。溶媒均为0.9%氯化钠注射液。单次给药剂量以8mL为主,用法均为静脉滴注。用药疗程≤10d的占80.59%。使用该药并没有缩短患者的住院天数(r=0.374,P <0.05)。观察期间不良反应发生率为0。用药并没有减少切口感染的发生(P> 0.05)。结论该药安全性良好,促进术后愈合的有效性尚不明确。我院存在滥用的现象,应规范使用。Objective To understand the actual application of placental polypeptide injection on postoperative patients,and to provide reference for clinical rational medication. Methods From January 2016 to December 2019,2153 inpatients who were treated with placental polypeptide injection after operation and 32 520 patients who were not treated with it after operation in the same period admitted to our hospital were selected by HIS system.Statistical analysis was performed from the aspects of medicine takers,solvent types,usage and dosage,medication course,incision healing and adverse reactions(ADRs). Results The ages of medicine takers were concentrated in 18-44 years old,and the ratio of male to female was 1 ∶ 1.The solvent was 0.9% sodium chloride injection.The single administration dose was mainly 8 mL,and the usage was intravenous drip.80.59% patients were treated for less than or equal to 10 days.The usage of medicine did not shorten the hospitalization days(r=0.374,P < 0.05).The incidence of ADRs during the observation period was 0.Medication did not reduce the incidence of incision infection(P > 0.05). Conclusion The medicine is safe,and its efficacies in promoting postoperative healing are unclear.Medicine abuse exists in our hospital,so it should be used in a standardized way.

关 键 词：胎盘多肽注射液 真实世界研究 有效性 安全性 

分 类 号：R978[医药卫生—药品]