肿瘤标志物在卵巢癌诊断中的临床意义  

Clinical Significance of Tumor Markers in the Diagnosis of Ovarian Cancer

作　　者：蔡胜男[1] 施中凯[1] 韩桂文[1] 徐桂霞[1] CAI Shengnan;SHI Zhongkai;HAN Guiwen;XU Guixia(Radioimmunoassay Unit,Heilongjiang Provincial Hospital,Harbin Heilongjiang 150036,China)

机构地区：[1]黑龙江省医院放射免疫特检科,黑龙江哈尔滨150036

出　　处：《中国卫生标准管理》2020年第18期108-109,共2页China Health Standard Management

摘　　要：目的观察糖类抗原125(carbohydrate antigen 125,CA125)、糖类抗原199(carbohydrate antigen 199,CA199)联合癌胚抗原(carcinoembryonic antigen,CEA)用于诊断卵巢癌的临床意义。方法回顾性总结本院2018年12月—2019年12月收治的80例卵巢癌病例(观察A组)与80例良性卵巢病变患者(观察B组)的临床资料,并选择同期80例健康体检者为对照组。三组均给予上述肿瘤标志物的检测,并比较相关结果。结果 (1)观察A组血清CA125、CA199以及CEA水平分别为(390.4±15.8)U/mL、(135.4±16.1)U/mL、(20.4±2.6)ng/mL;观察B组分别为(20.1±2.8)U/mL、(15.4±2.3)U/mL、(4.2±1.1)ng/mL;对照组分别为(12.3±1.9)U/mL、(12.4±2.5)U/mL、(2.1±0.8)ng/mL;观察A组上述指标水平显著高于观察B组和对照组,差异均有统计学意义(P <0.05)。(2)观察A组中CA125的灵敏度为72.50%(58/80);CA199为43.75%(35/80);CEA为25.00%(20/80),三种指标联合检测的灵敏度为90.00%(72/80),差异有统计学意义(χ2=10.479,11.883,15.681,P <0.05)。结论 CA125、CA199以及CEA联合检测能够明显提高卵巢癌的准确率。Objective To observe the clinical significance of carbohydrate antigen 125(CA125)and carbohydrate antigen 199(CA199)combined with carcinoembryonic antigen(CEA)in the diagnosis of ovarian cancer.Methods The clinical data of 80 cases of ovarian cancer(observation group A)and 80 patients with benign ovarian disease(observation group B)treated in our hospital from December 2018 to December 2019 were retrospectively summarized,and 80 healthy subjects during the same period were selected.All three groups were given the above tumor markers and compared the relevant results.Results(1)The serum CA125,CA199 and CEA levels of group A were(390.4±15.8)U/mL,(135.4±16.1)U/mL,(20.4±2.6)ng/mL;group B were(20.1±2.8)U/mL,(15.4±2.3)U/mL,(4.2±1.1)ng/mL;the control group is(12.3±1.9)U/mL,(12.4±2.5)U/mL,(2.1±0.8)ng/mL;the above-mentioned index levels in group A were significantly higher than those in group B and control group,the differences were statistically significant(P<0.05).(2)The sensitivity of CA125 in group A was 72.50%(58/80),CA199 was 43.75%(35/80),CEA was 25.00%(20/80),the sensitivity of the combined detection of the three indicators was 90.00%(72/80),the differences were statistically significant(χ2=10.479,11.883,15.681,P<0.05).Conclusion The combined detection of CA125,CA199 and CEA can significantly improve the accuracy of ovarian cancer.

关 键 词：血清 肿瘤标志物 卵巢癌 准确度 灵敏度 特异度 

分 类 号：R446[医药卫生—诊断学]