尼可地尔对不稳定型心绞痛患者行经皮冠状动脉介入术的效果分析  

Analysis of the Effect of Nicorandil on Patients with Unstable Angina Pectoris Percutaneous Coronary Intervention

作　　者：胡晴[1] 宫磊[2] 杨帆[3] 高江彦[1] HU Qing;GONG Lei;YANG Fan;GAO Jiang-yan(Department of Cardiology,Hebei Chest Hospital,Shijiazhuang,Hebei Province,050041 China;Department of Nephrology,Hebei Chest Hospital,Shijiazhuang,Hebei Province,050041 China;Department of Tuberculosis,Hebei Chest Hospital,Shijiazhuang,Hebei Province,050041 China)

机构地区：[1]河北省胸科医院心内科,河北石家庄050041 [2]河北省胸科医院肾内科,河北石家庄050041 [3]河北省胸科医院结核二科,河北石家庄050041

出　　处：《世界复合医学》2020年第7期158-160,共3页World Journal of Complex Medicine

摘　　要：目的观察经皮冠状动脉介入治疗(PCI)术后尼可地尔对不稳定型心绞痛(USA)患者的影响,探讨该药的应用效果。方法选择2017年4月—2019年4月于该院接受治疗的USA患者共70例,依随机数字表法分为观察组及对照组,每组35例。与PCI术后,对照组采用常规治疗,观察组则在对照组基础上联合尼可地尔治疗。对比两组血管内皮功能指标[血管内径变化率(FMD)、内皮素1(ET-1)]与心肌损伤标志物[心肌肌钙蛋白Ⅰ(cTnⅠ)、肌酸激酶同工酶(CK-MB)]水平及心血管不良事件(MACE)发生率。结果治疗后,观察组FMD水平(20.12±2.70)%比对照组(17.82±2.48)%高,ET-1水平(54.69±8.45)ng/L比对照组(62.78±8.84)ng/L低,差异有统计学意义(P<0.05);治疗后,观察组cTnⅠ(2.27±1.10)μg/L、CK-MB(3.09±1.05)U/L水平比对照组(4.82±1.48)μg/L、(6.38±1.84)U/L低,差异有统计学意义(P<0.05);治疗期间,观察组MACE发生率2.86%比对照组11.43%略低,差异无统计学意义(P>0.05)。结论PCI术后应用尼可地尔可有效改善USA患者的血管内皮功能与心肌损伤状况,并可一定程度上降低MACE发生率。Objective To observe the effect of nicorandil on patients with unstable angina pectoris(USA)after percutaneous coronary intervention(PCI),and to explore the application effect of the drug.Methods A total of 70 patients from USA who were treated in our hospital from April 2017 to April 2019 were selected and divided into observation group and control group according to random number table method,35 cases in each group.After PCI,the control group received conventional treatment,and the observation group received nicorandil treatment based on the control group.Compare the two groups of vascular endothelial function indexes[vascular inner diameter change rate(FMD),endothelin 1(ET-1)]and myocardial injury markers[cardiac troponin I(cTnI),creatine kinase isoenzyme(CK-MB)]level and incidence of adverse cardiovascular events(MACE).Results After treatment,the FMD level of the observation group(20.12±2.70)%was higher than that of the control group(17.82±2.48)%,and the ET-1 level(54.69±8.45)ng/L was lower than that of the control group(62.78±8.84)ng/L.The difference was statistically significant(P<0.05);after treatment,the cTnⅠ(2.27±1.10)μg/L and CK-MB(3.09±1.05)U/L levels of the observation group were higher than those of the control group(4.82±1.48)μg/L,(6.38±1.84)U/L,the difference was statistically significant(P<0.05);during treatment,the incidence of MACE in the observation group was 2.86%slightly lower than that in the control group 11.43%,the difference was not statistically significant(P>0.05).Conclusion The application of nicorandil after PCI can effectively improve the vascular endothelial function and myocardial injury of USA patients,and can reduce the incidence of MACE to a certain extent.

关 键 词：不稳定型心绞痛 经皮冠状动脉介入治疗 尼可地尔 心血管 

分 类 号：R541.4[医药卫生—心血管疾病]