Duff反应合成2-羟基-1-萘甲醛的研究  

Synthesis of the 2-Hydroxy-1-naphthaldehyde by the Duff Reaction

作　　者：徐虹[1,2] 吕宏飞[1,2] 吴绵园 李淑辉[1] 梅立鑫 杨杰[1] 白雪峰[1,2] 李猛[1,2] XU Hong;LV Hong-fei;WU mian-yuan;LI Shu-hui;MEI Li-xin;YANG Jie;BAI Xue-feng;LI Meng(Institute of Advanced Technology,Heilongjiang Academy of Sciences,Harbin 150020,China;Institute of Petrochemistry,Heilongjiang Academy of Sciences,Harbin 150040,China)

机构地区：[1]黑龙江省科学院高技术研究院,黑龙江哈尔滨150020 [2]黑龙江省科学院石油化学研究院,黑龙江哈尔滨150040

出　　处：《化学与粘合》2020年第5期334-336,共3页Chemistry and Adhesion

基　　金：黑龙江省科学院科学研究基金(编号:KY2019SH02)。

摘　　要：2-羟基-1-萘甲醛是一种重要中间体,在医药、染料、农用杀虫剂、香料等领域有着广泛的用途。以2-萘酚为原料,通过Duff反应得到2-羟基-1-萘甲醛。实验考察了反应温度和乌洛托品用量的不同对收率的影响。最佳工艺条件如下:n(2-萘酚)∶n(乌洛托品)=1∶1.6,反应时间为4h,反应温度为85℃。在此条件下反应收率为69.0%,纯度为99.6%。采用的工艺路线合理,产品收率高。The 2-hydroxy-1-naphthaldehyde is confirmed as an important intermediate and has a wide range of applications in the fields of medicine,dyes,agricultural pesticides and spices,etc.The 2-hydroxy-1-naphthaldehyde is synthesized from 2-hydroxynaphthalene by the Duff reac-tion.The effects of temperature and hexamethylenetetramine usage on the yield are discussed.The optimal process conditions have been obtained as follows:n(2-hydroxynaphthalene):n(hexamethylenetetramine)=1:1.6,the reaction time is 4 h,the reaction temperature is 85℃.The yield is 69.0%with 99.6%purity.The adopted process route is reasonable with high yield.

关 键 词：2-羟基-1-萘甲醛 Duff反应 合成 

分 类 号：O625.41[理学—有机化学]