散结膏外敷联合中医定向透药治疗仪治疗甲状腺结节临床研究  

Clinical Study on Ointment for Thyroid Nodules for External Application in Combination with TCM Directional Penetration Therapy Instrument in Treating Thyroid Nodules

作　　者：柴淑芳 林卫 沈洁 巩浩 徐李娜 杨其良 CHAI Shu-fang;LIN Wei;SHEN Jie;GONG Hao;XU Li-na;YANG Qi-liang(Jinshan District Tinglin Hospital of Shanghai,Shanghai,China,201515)

机构地区：[1]上海市金山区亭林医院,上海201515

出　　处：《河南中医》2020年第10期1544-1547,共4页Henan Traditional Chinese Medicine

基　　金：上海市金山区科学技术创新资金项目(2018-3-13)。

摘　　要：目的:观察散结膏外敷联合中医定向透药治疗仪治疗甲状腺结节(thyroid nodules,TN)的临床疗效。方法:将90例TN患者按照随机数字表法分为治疗组和对照组,每组各45例。对照组在常规治疗的基础上给予海藻玉壶汤口服治疗,治疗组在对照组基础上给予自拟散结膏外敷并配合中医定向透药治疗仪治疗。观察两组患者临床疗效,比较两组患者治疗前后中医证候积分、结节最大直径、甲状腺功能[促甲状腺激素(thyroid stimulating hormone,TSH)、血清游离三碘甲状腺激素(free three iodine thyroid hormone,FT3)、游离四碘甲状腺激素(Free four iodine thyroid hormone,FT4)]、甲状腺自身免疫抗体[甲状腺过氧化物酶抗体(thyroid peroxidase antibody,TPOAb)、甲状腺球蛋白抗体(thyroglobulin antibody,TGAb)]变化情况。结果:治疗组有效率为95.56%,对照组有效率为80.00%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后颈前喉结两旁肿块、胸闷、纳差、胸胁胀满等中医证候积分均低于本组治疗前,且治疗组治疗后低于对照组治疗后,差异具有统计学意义(P<0.05)。两组患者治疗后结节最大直径小于本组治疗前,且治疗组治疗后小于对照组治疗后,差异具有统计学意义(P<0.05)。两组患者治疗后TSH、TPOAb、TGAb水平低于本组治疗前,且治疗组低于同期对照组;两组患者治疗后FT3、FT4水平高于本组治疗前,且治疗组高于同期对照组,差异具有统计学意义(P<0.05)。结论:散结膏外敷联合中医定向透药治疗仪治疗TN,能有效改善患者临床症状及甲状腺水平。Objective:To observe the clinical curative effect of Ointment for Thyroid Nodules for external application in combination with TCM directional penetration therapy instrument on thyroid nodules(TN).Methods:A total of 90 patients with TN were divided into the treatment group and the control group according to random number table method,with 45 cases in each group.The control group was given Haizao Yuhu Decoction(海藻玉壶汤,HZYHD) on the basis of conventional treatment,while the treatment group was given external application of Self-Made Ointment for Thyroid Nodules for external application in combination with TCM directional penetration therapy instrument on the basis of the control group.The clinical efficacy of the two groups was observed.The changes of TCM syndrome score,maximum diameter of nodule,thyroid function [including thyroid stimulating hormone(TSH),free three iodine thyroid hormone(FT3) and free four iodine thyroid hormone(FT4)],thyroid autoimmune antibody [including thyroid autoimmune antibody(TPOAb) and thyroglobulin antibody(TGAb)] before and after the treatment were compared between the two groups.Results:The effective rate of the treatment group was 95.56%,and that of the control group was 80.00%.The difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as mass on both sides of the neck and laryngeal node,chest tightness,anorexia,fullness of chest and flank were lower than those of the same group before treatment in the two groups,and the above indexes of the treatment group were lower than those of the control group after treatment,and all the differences were statistically significant(P<0.05).After the treatment,the maximum diameter of nodules in the two groups was smaller than that of the same group before the treatment,and the maximum diameter of nodules in the treatment group was smaller than that in the control group after treatment,the difference was statistically significant(P<0.05).After the treatment,the levels of TSH,TPOAb and TGAb in

关 键 词：甲状腺结节 散结膏 外敷 中医定向透药治疗仪 海藻玉壶汤 

分 类 号：R259.813[医药卫生—中西医结合]