糖尿病足发病机制研究进展  

Research Progress on Pathogenesis of Diabetic Foot

作　　者：何元旭 何志军[2] 刘涛 陈梓瑜 王海刚 HE Yuan-xu;HE Zhi-jun;LIU Tao;CHEN Zi-yu;WANG Hai-gang(Gansu University of Chinese Medicine,Lanzhou,Gansu,China,730000;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou,Gansu,China,730050)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院,甘肃兰州730050

出　　处：《河南中医》2020年第10期1614-1617,共4页Henan Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81660802,81860863)。

摘　　要：糖尿病足的发病机制较为复杂,多种损伤机制相互作用,目前研究公认的发病机制有周围血管病变、周围神经病变以及在周围神经血管病变基础上的感染,其他发病机制如:氧化应激、相关通路、基因遗传等。针对糖尿病足,相关学者依据中医学理论提出多种病机学说,可用于指导临床辨证施治,首先络病学说与周围血管病变关系密切,其中感染又可归之于外毒侵袭,毒损脉络;其次玄府理论与周围神经病变又有相通之处,脏腑学说贯穿疾病发展始终。今后,在治疗过程中能够更好地发挥中医与西医各自的优势,提高糖尿病足的治疗水平。The pathogenesis of diabetic foot is more complex,and a variety of injury mechanisms interact.At present,the commonly recognized pathogenesis of diabetic foot includes peripheral vascular disease,peripheral neuropathy and infection based on peripheral neuropathy.There are other pathogeneses such as oxidative stress,related pathways,genetic inheritance,etc.For diabetic foot,relevant scholars put forward a variety of pathogenesis theories according to the theory of TCM,which can be used to guide clinical treatment based on syndrome differentiation.First of all,the theory of collateral disease is closely related to peripheral vascular lesions,in which infection can be attributed to the invasion of exogenous toxin which damages the veins.Secondly,sweat pore theory has something in common with peripheral neuropathy,while viscera theory runs through the development of diseases.In the future,it is necessary to give full play to the advantages of TCM and Western medicine in the treatment process,and improve the treatment level of diabetic foot.

关 键 词：糖尿病足 中医病机 发病机制 络病学说 玄府理论 脏腑学说 周围血管疾病 周围神经病变 感染 

分 类 号：R259.871[医药卫生—中西医结合]