信号分子介导藻类细胞程序性死亡的研究进展  

RESEARCH ADVANCES OF SIGNALING MOLECULES-MEDIATED ALGAE CELL DEATH SIMILAR TO PROGRAMMED CELL DEATH

作　　者：黄素珍 张璐[1] 彭雪 葛芳杰[1] 刘碧云[1] 周巧红[1] 吴振斌[1] HUANG Su-Zhen;ZHANG Lu;PENG Xue;GE Fang-Jie;LIU Bi-Yun;ZHOU Qiao-Hong;WU Zhen-Bin(State Key Laboratory of Freshwater Ecology and Biotechnology,Institute of Hydrobiology,Chinese Academy of Sciences,Wuhan 430072,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院水生生物研究所淡水生态与生物技术国家重点实验室,武汉430072 [2]中国科学院大学,北京100049

出　　处：《水生生物学报》2020年第5期1014-1019,共6页Acta Hydrobiologica Sinica

基　　金：国家自然科学基金重点项目(31830013);武汉市科学技术计划应用基金会前沿特别项目(2019020701011491);宁夏回族自治区重点研究发展规划(2017BY087)资助。

摘　　要：藻类是水生态系统中的重要初级生产者,在物质转换和能量迁移过程中发挥重要作用。细胞程序性死亡(PCD)作为一种细胞自我调控的死亡模式,受到多种信号分子的控制。研究发现藻类细胞在遭受环境胁迫的情况下,在形态和生理上均表现出类PCD的特征,同时伴随着活性氧/一氧化氮/钙离子(ROS/NO/Ca^2+)水平的变化。研究认为, ROS/NO/Ca^2+作为信号分子介导藻细胞内的caspase-like酶活性变化,从而触发藻细胞的类程序性死亡。然而,对信号分子是如何在环境胁迫下的藻类细胞中引发类PCD仍知之甚少。文章综述了信号分子ROS/NO/Ca^2+介导藻类类PCD的研究进展以及信号分子间的级联关系,并对今后类PCD在该领域待开展的研究进行了展望。Algae are important primary producer in aquatic ecosystems and play an important role in the process of material conversion and energy migration.Programmed cell death(PCD)is a self-regulated cell death mode that is controlled by different signaling pathways.Studies have found that when algae are subjected to environmental stress,the algal cells exhibit PCD characteristics in morphology and physiology,accompanying with the changes of reactive oxygen species/nitric oxide/calcium ions(ROS/NO/Ca^2+ )levels.The researchers speculated that ROS/NO/Ca^2+ maybe be a signaling molecule to mediate the changes of Caspase-like enzyme activity in algae cells and trigger a process similar to programmed cell death.However,little is known about how signaling molecules trigger a process similar to PCD in algae cells under environmental stress.This paper reviews the research progress of signal molecule ROS/NO/Ca^2+ mediating the process similar to PCD in algae cells and the cascade effect between signal molecules.Finally,future research in this field similar to PCD is prospected.

关 键 词：藻类 类细胞程序性死亡 信号分子 活性氧 一氧化氮 CA^2+ 

分 类 号：Q173[生物学—水生生物学]