基于网络药理学探究车前子治疗慢性前列腺炎的作用机制研究  

Research on the Mechanism of Plantain Seed in the Treatment of Chronic Prostatitis Based on Network Pharmacology

作　　者：蒋鹏[1] 高宏君[1] 梁泰生[1] 吴玲玲 武桢[1] 

机构地区：[1]广西中医药大学附属瑞康医院,广西南宁530011

出　　处：《大众科技》2020年第8期50-55,共6页Popular Science & Technology

基　　金：广西壮族自治区中青年教师基础能力提升项目(2019KY0317);广西中医药大学2019-2011年广西一流学科建设项目青年基金项目(2019XK176);广西壮族自治区中青年教师基础能力提升项目(KY2015LX144)。

摘　　要：目的:利用网络药理学探究车前子治疗慢性前列腺炎的作用机理。方法:通过中药系统药理学技术平台(TCMSP)数据库,以化合物口服药物生物利用度(OB)和类药性(DL)为标准,预测并筛选车前子的化合物及作用靶点。通过Gene Cards数据库筛选慢性前列腺炎的靶标基因,通过Venny2.1数据库获得车前子对慢性前列腺炎的相关靶点,应用STRING数据库进行蛋白互作网络分析,以Cytoscape3.6.1软件构建车前子化合物-靶点网络图,利用David6.8数据库进行GO分析和KEGG信号通路富集分析。结果:从车前子中筛选获得包括7个化学成分,作用于23个慢性前列腺炎靶点,主要靶点包括抗肿瘤P53抗体、雄激素受体、白细胞介素6、白细胞介素1、表皮生长因子、BCL2凋亡调节器、血管内皮细胞生长因子A等。结论:车前子可能主要通过抗炎、抗氧化、扩张血管、抑制细胞凋亡等方面来治疗慢性前列腺炎。Objectives:To explore the mechanism of plantain seed in the treatment of chronic prostatitis by network pharmacology.Methods:Through the Chinese medicine system pharmacology technology platform(TCMSP)database,the bioavailability(OB)and drug like(DL)of oral drugs were used as the standards to predict and screen the plantain seed compounds and targets.Target genes for chronic prostatitis were screened by Gene Cards database.Venny2.1 tool was used to obtain relevant targets of plantain seed for chronic prostatitis.The protein interaction network was analyzed by STRING database.Cytoscape3.6.1 software was used to construct the plantain seed compound target network diagram.GO analysis and KEGG pathway enrichment analysis were carried out using David6.8 database.Results:7 chemical components were screened from plantain seed,acting on 23 targets of chronic prostatitis.The main targets include tumor protein P53,androgen receptor,interleukin 6,interleukin 1,epidermal growth factor,BCL2 apoptosis regulator,vascular endothelial growth factor A,etc.Conclusion:Plantain seed may treat chronic prostatitis mainly through anti-inflammatory,anti-oxidation,vasodilation,inhibition of apoptosis and other aspects.

关 键 词：车前子 慢性前列腺炎 网络药理学 作用机制 

分 类 号：R697[医药卫生—泌尿科学]