泌尿系结石首次发现年龄与病程长短和肾功能损伤相关  

Age of onset and course of urinary stone are related with renal function damage

作　　者：乔逸[1] 肖河[1] 樊晓红[2] 石冰冰[1] 纪志刚[1] 李汉忠[1] QIAO Yi;XIAO He;FAN Xiao-hong;SHI Bing-bing;JI Zhi-gang;LI Han-zhong(Department of Urology,Peking Union Medical College Hospital,CAMS&PUMC,Beijing 100730,China;Department of Nephrology,Peking Union Medical College Hospital,CAMS&PUMC,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院泌尿外科,北京100730 [2]中国医学科学院北京协和医学院北京协和医院肾内科,北京100730

出　　处：《基础医学与临床》2020年第10期1385-1388,共4页Basic and Clinical Medicine

摘　　要：目的评价泌尿系结石患者中结石首次发现年龄与病程长短等与肾功能损伤的相关性。方法回顾性收集北京协和医院泌尿外科2016年5月至2020年5月进行代谢评估的183例患者的情况,资料包括患者首次发现结石的年龄、结石病程长短以及患者肾小球滤过率(eGFR)情况等。利用多元线性回归方法评估首次发现结石的年龄、结石病程长短等因素与患者eGFR之间的相关性,以说明泌尿系结石对患者肾功能的影响。结果本研究发现,肾功能分级越高,泌尿系结石患者的平均病程更长。而在肾功能1~3级的结石患者中,肾功能分级越高,患者首次发现结石的平均年龄越大。利用多元线性回归方法分析显示,首次发现结石的年龄、结石病程长短与患者eGFR之间存在线性相关性。结论泌尿系结石患者首次发现结石的年龄越大、结石病程越长,对患者肾功能损伤越明显、eGFR越低。Objective To evaluate the correlation of age of onset,course of stone with renal function among urinary stone patients.Methods Totally 183 patients history data were reviewed,including age of onset for stone,course of stone and eGFR.We evaluated correlation of age of onset,course of stone with eGFR by multivariate linear regression,to find potential relationship of urinary stone with renal function damage.Results With higher level of renal function,mean course of stone was longer among urinary stone patients.Meanwhile,among patients with renal function at 1-3 level,mean age of onset also increased as level of renal function increasing.Furthermore,multivariate linear regression revealed that age of onset,course of stone and eGFR were in linear correlation.Conclusions With older age of onset for stone and/or longer course of stone,patients renal function is impaired more seriously with lower eGFR among urinary stone patients.

关 键 词：泌尿系结石 首次发现年龄 病程长短 肾功能 

分 类 号：R691.4[医药卫生—泌尿科学]