Biointerface engineering nanoplatforms for cancer-targeted drug delivery  

作　　者：Huaiyu Zhang Shujun Dong Zhongmin Li Xiangru Feng Weiguo Xu Catrina Mae STulinao Yang Jiang Jianxun Ding 

机构地区：[1]Department of Gastrointestinal Colorectal and Anal Surgery,China-Japan Union Hospital of Jilin University,Changchun 130033,China [2]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [3]VIP Integrated Department,School and Hospital of Stomatology,Jilin University,Changchun 130021,China [4]Far Eastern University-Nicanor Reyes Medical Foundation,Quezon City 1118,Philippines

出　　处：《Asian Journal of Pharmaceutical Sciences》2020年第4期397-415,共19页亚洲药物制剂科学（英文）

基　　金：Financially supported by the National Natural Science Foundation of China(Grant Nos.51973216,51873207,51803006,51673190,51603204,51673187,and 51520105004);the Science and Technology Development Program of Jilin Province(Grant Nos.20190201068JC,20170101102JC,and 20160414047GH);the Medical and Health Program of Jilin Province(Grant No.20190304047YY);the Youth Talents Promotion Project of Jilin Province(Grant No.181909);and the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.2019005).

摘　　要：Over the past decade,nanoparticle-based therapeutic modalities have become promising strategies in cancer therapy.Selective delivery of anticancer drugs to the lesion sites is critical for elimination of the tumor and an improved prognosis.Innovative design and advanced biointerface engineering have promoted the development of various nanocarriers for optimized drug delivery.Keeping in mind the biological framework of the tumormicroenvironment,biomembrane-camouflaged nanoplatforms have been a research focus,reflecting their superiority in cancer targeting.In this review,we summarize the development of various biomimetic cell membrane-camouflaged nanoplatforms for cancertargeted drug delivery,which are classified according to the membranes fromdifferent cells.The challenges and opportunities of the advanced biointerface engineering drug delivery nanosystems in cancer therapy are discussed.

关 键 词：Cell membrane-camouflaged nanoplatform BIOFUNCTIONALIZATION Tumor microenvironment Controlled drug delivery Targeted cancer therapy 

分 类 号：R943[医药卫生—药剂学]