T2DM合并高血压患者血浆Hcy与心踝血管指数相关性分析  

Correlation analysis of plasma homocysteine and cardio-ankle vascular index in T2DM patients complicated with hypertension

作　　者：曹慧[1] 朱璇璇 Cao Hui;Zhu Xuanxuan(Xinyi Railway Hospital,Xinyi 221400)

机构地区：[1]江苏省新沂市铁路医院,221400

出　　处：《中国现代医药杂志》2020年第9期38-42,共5页Modern Medicine Journal of China

摘　　要：目的探讨2型糖尿病(T2DM)合并高血压患者血浆同型半胱氨酸(Hcy)与心踝血管指数(CAVI)的相关性。方法收集符合入选标准的T2DM合并高血压患者120例,记录患者一般资料,测定其空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、颈动脉内膜中层厚度(IMT)、血浆Hcy水平和CAVI,分析Hcy与CAVI的关系及相关影响因素。结果①CAVI中位数9.55,根据CAVI四分位数将患者分为4组,分别为:Q1组CAVI≤8.42(n=29),Q2组CAVI 8.42~9.55(n=31),Q3组CAVI 9.55~10.68(n=28),Q4组CAVI≥10.68(n=32)。4组间年龄、收缩压、BMI、LDL-C、Hcy、IMT水平差异均存在统计学意义(P<0.05);②Q4组Hcy水平显著高于Q1、Q2、Q3组(P<0.05),Hcy与CAVI呈正相关(P<0.05);③CAVI与年龄、收缩压、IMT呈正相关(P<0.05),与LDL-C呈负相关(P<0.05);④多元回归分析结果显示,年龄、IMT、Hcy为动脉硬化发生发展的独立危险因素。结论Hcy对T2DM合并高血压患者动脉硬化有一定影响,年龄、IMT、Hcy为动脉硬化发生发展的独立危险因素。Objective To investigate the correlation between plasma homocysteine(Hcy)and cardio-ankle vascular index(CAVI)in type 2 diabetes mellitus(T2DM)patients complicated with hypertension.Methods A total of 120 patients with T2DM and hypertension who met the inclusion criteria were collected,and the general data of the patients were recorded.Determined the levels of fasting blood glucose(FBG),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),carotid intima-media thickness(IMT),plasma Hcy and CAVI.The relationship between Hcy and CAVI and the related influencing factors were analyzed.Results①Median CAVI was 9.55,according to the CAVI quartile,the patients were divided into four groups:CAVI≤8.42 in Q1 group(n=29);CAVI 8.42~9.55 in Q2 group(n=31);CAVI 9.55~10.68 in Q3 group(n=28);CAVI≥10.68 in Q4 group(n=32).There were statistical differences in age,systolic blood pressure,BMI,LDL-C,Hcy and IMT levels among the four groups(P<0.05);②Hcy level in Q4 group was significantly higher than that in Q1,Q2,and Q3 group(P<0.05).Hcy was positively correlated with CAVI(P<0.05);③CAVI level was positively correlated with age,systolic blood pressure and IMT(P<0.05),negatively correlated with LDL-C(P<0.05);④The results of multiple regression analysis showed that age,IMT and Hcy were independent risk factors for the development of atherosclerosis.Conclusion Hcy has certain effect on arteriosclerosis in T2DM patients complicated with hypertension.Age,IMT and Hcy are independent risk factors for the development of atherosclerosis.

关 键 词：同型半胱氨酸 高血压 心踝血管指数 2 型糖尿病 颈动脉内膜中层厚度 

分 类 号：R587.2[医药卫生—内分泌] R544.1[医药卫生—内科学]