理气化痰、和胃利胆法对肝癌动脉栓塞术后细胞免疫和肝功能的影响  

Effects of Regulating Qi and Resolving Phlegm and Hewei Lidan Method on Toxic and Side Effects,Cellular Immunity and Liver Function After Hepatic Carcinoma Arterial Embolism

作　　者：于倩 王亚华[1] 李辉 王聃 葛时序 孟健[2] YU Qian;WANG Yahua;LI Hui;WANG Ran;GE Shixu;MENG Jian(Tangshan Chinese Medicine Hospital,Tangshan Hebei Beijing 063000;The Affiliated Hospital to Liaoning University of Chinese Medicine,Shenyang Liaoning China 110000)

机构地区：[1]唐山市中医医院,河北唐山063000 [2]辽宁中医药大学附属医院,辽宁沈阳110000

出　　处：《中医学报》2020年第10期2231-2235,共5页Acta Chinese Medicine

基　　金：河北省中医药管理局科技计划项目(2019224)。

摘　　要：目的:探讨理气化痰、和胃利胆法对肝癌动脉栓塞术后细胞免疫、肝功能的影响。方法:72例肝癌患者采用随机、双盲、平行对照的原则,分为试验组与对照组各36例。试验组给予动脉栓塞术^+理气化痰、和胃利胆法治疗,对照组给予动脉栓塞术^+安慰剂治疗。比较不同治疗方法对患者细胞免疫及肝功能的影响,评价近期疗效,并随访2年,观察生存情况。结果:治疗后两组患者白蛋白(albumin,ALB)水平较治疗前降低(P<0.05),丙氨酸氨基转移酶(alanine,ALT)、天冬氨酸氨基转移酶(aspartate,AST)、总胆红素(total bilirubin,TBIL)水平较治疗前升高(P<0.05),且试验组ALP水平高于对照组(P<0.05),ALT、AST、TBIL水平低于对照组(P<0.05),试验组肝功能优于对照组;治疗后两组CD4^+、CD4^+/CD8^+水平较治疗前降低(P<0.05),CD8^+水平较治疗前升高(P<0.05),且试验组CD4^+、CD4^+/CD8^+水平高于对照组(P<0.05),CD8^+水平低于对照组(P<0.05),试验组细胞免疫功能优于对照组;两组发热、恶心呕吐、腹部疼痛、失眠乏力等不良反应发生情况比较,试验组优于对照组(P<0.05);治疗后两组中医证候积分较治疗前均有明显下降(P<0.05),且试验组中医证候积分低于对照组(P<0.05),试验组中医症状改善更为明显;两组近期疗效以及6个月、1年生存率比较,无显著差异(P>0.05),试验组2年生存率和2年生存时间优于对照组(P<0.05)。结论:理气化痰、和胃利胆法能够显著降低肝癌动脉栓塞术后不良反应,减少其对肝功能和细胞免疫功能的损害,有利于延长生存期。Objective:To explore the effects of regulating Qi,resolving Phlegm and Hewei Lidan method on the side effects,cellular immunity,and liver function after hepatic carcinoma arterial embolization.Methods:72 patients with liver cancer were randomly divided into double-blind,parallel control principles,divided into experimental group and control group,with 36 cases in each group.The experimental group was treated with arterial embolization^+regulating Qi and reducing phlegm,and the stomach and gallbladder method,and the control group was given arterial embolization^+placebo.Compare the effects of different treatment methods on patients′toxic and side effects,cellular immunity and liver function;evaluate the short-term efficacy and follow up for 2 years to observe the survival.Results:After treatment,the levels of albumin(ALB)decreased(P<0.05),alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)increased(P<0.05),and the ALP level in the test group was higher than the control group(P<0.05),ALT,AST,and TBIL levels were lower than the control group(P<0.05),liver function in the test group Higher than the control group;after treatment,the levels of CD4^+,CD4^+/CD8^+decreased(P<0.05),the level of CD8^+increased(P<0.05),and the levels of CD4^+,CD4^+/CD8^+in the test group were higher than the control group(P<0.05)The level of CD8^+is lower than that of the control group(P<0.05),and the cellular immune function of the test group is higher than that of the control group;there are significant differences in the occurrence of toxic and side effects such as fever,nausea and vomiting,abdominal pain,insomnia and fatigue in the two groups(P<0.05)The incidence of toxic and side effects in the test group was better than that in the control group;after treatment,the TCM syndrome scores of both groups decreased significantly(P<0.05),and the TCM syndrome scores of the test group were lower than the control group(P<0.05),TCM symptoms in the test group The improvement was more obvious;the short-term efficac

关 键 词：理气化痰、和胃利胆法 肝癌 动脉栓塞术 细胞免疫 肝功能 

分 类 号：R273[医药卫生—中西医结合]