3-硝基邻苯二甲酸二甲酯的合成  

Synthesis of Dimethyl 3-nitrophthalate

作　　者：王杨洋 侯海超 左志芳[1] 罗志臣[1] WANG Yang-yang;HOU Hai-chao;ZUO Zhi-fang;LUO Zhi-chen(Department of Chemical Engineering,Yangzhou Polytechnic Institute,Jiangsu Yangzhou 225127,China)

机构地区：[1]扬州工业职业技术学院化学工程学院,江苏扬州225127

出　　处：《广州化工》2020年第19期38-39,共2页GuangZhou Chemical Industry

基　　金：江苏省大学生创新创业训练计划一般项目(项目编号:201913754004Y)。

摘　　要：3-硝基邻苯二甲酸二甲酯可作为抗肿瘤药物的中间体。实验以3-硝基邻苯二甲酸酐和甲醇为原料,以聚苯胺负载杂多酸作为固体催化剂,合成了3-硝基邻苯二甲酸二甲酯,实验研究了酸酐和醇的配比,催化剂用量,反应时间对酯化率的影响。实验结果表明最优的工艺条件为:n(3-硝基邻苯二甲酸酐):n(甲醇)=1:15,催化剂用量为5%,反应4.5 h,合成产率可达到90.1%。Dimethyl 3-nitrophthalate can be used as the intermediate of antitumor drugs.In this experiment,dimethyl 3-nitrophthalate was synthesized from 3-nitrophthalic anhydride and methanol,using polyaniline supported heteropolyacid as solid catalyst.The effects of the ratio of anhydrides to alcohols,catalyst dosage and reaction time on the synthesis process were studied.The results showed that when n(3-nitrophthalic anhydride):n(methanol)was 1:15,the amount of catalyst was 5%,and reaction time was 4.5 h,the yield reached 90%.

关 键 词：3-硝基邻苯二甲酸酐 甲醇 酯化 3-硝基邻苯二甲酸二甲酯 

分 类 号：TQ20[化学工程—有机化工]