174例妊娠期肝内胆汁淤积症孕妇母儿结局临床分析  

Clinical Analysis of Maternal and Fetal Outcomes in 174 Pregnant Women with Intrahepatic Cholestasis of Pregnancy

作　　者：万彦婷[1] 李芳[2] 洪燕[1] 辛思明[2] 刘先先 赖华[2] WAN Yan-ting;LI Fang;HONG Yan;XIN Si-ming;LIU Xian-xian;LAI Hua(Hospital of Jiangxi Provincial Armed Police Corps,Nanchang 330002,China;Department of Obstetrics,Jiangxi Maternal and Child health Care Hospital,Nanchang 330006,China)

机构地区：[1]武警江西总队医院,南昌330002 [2]江西省妇幼保健院,南昌330006

出　　处：《江西中医药大学学报》2020年第5期39-42,共4页Journal of Jiangxi University of Chinese Medicine

基　　金：江西省科技厅项目(20192BBG70003)。

摘　　要：目的:分析妊娠期肝内胆汁淤积症患者临床指标与妊娠不良母儿结局的关系。方法:取174例ICP患者为观察对象(82例轻度组,92例重度组),取60例同期正常孕妇对照。比较三组孕妇临床指标及母儿结局,并将相关指标纳入Logistic回归分析模型,分析导致不良妊娠结局的危险因素。结果:三组孕妇CHOL、TG水平、羊水分度、产后出血量、新生儿出生体重无统计学差异(P>0.05);早产率有显著差异,经过诊断及治疗后轻度组平均延长妊娠天数3.1天,重度组平均延长妊娠天数3.5天(P<0.01);孕妇分娩方式比较有显著差异(P<0.01)。结论:血TBA水平是导致不良妊娠结局的危险因素,降低胆酸水平,可减少母儿不良结局的出现。Objective:To analyze the relationship between clinical indicators of intrahepatic cholestasis of pregnancy(ICP)and adverse outcomes of maternal and infant.Methods:174 cases of ICP patients(82 cases in mild group,92 cases in severe group)were selected as observation subjects,and 60 cases of normal pregnant women in the same period were selected as control subjects.The clinical indicators and maternal and child outcomes of pregnant women in the three groups were compared,and the relevant indicators were incorporated into the Logistic regression analysis model to analyze the risk factors leading to adverse pregnancy outcomes.Results:There were no statistically significant differences in CHOL,TG level,Amniotic fluid graduation,Amount of postpartum hemorrhage,and neonatal birth weight among the three groups(P>0.05).There was significant difference in the rate of preterm birth.After diagnosis and treatment,the average length of pregnancy was extended by 3.1 days in the mild group and 3.5 days in the severe group(P<0.01).There was significant difference in delivery mode among pregnant women(P<0.01).Conclusions:Blood TBA level is a risk factor leading to adverse pregnancy outcomes.Reducing cholic acid level can reduce the occurrence of adverse outcomes of maternal and child.

关 键 词：妊娠期肝内胆汁淤积症 TBA水平 不良妊娠结局 危险因素 

分 类 号：R271.9[医药卫生—中西医结合]