IgA肾病相关的免疫细胞膜分子及系膜细胞激活的研究进展  

Advances in the activation of immune cell membrane molecules and mesangial cells associated with IgA nephropathy

作　　者：赵成波 曾欢 王润秀[1] 谢富华 ZHAO Cheng-bo;ZENG Huan;WANG Run-xiu;XIE Fu-hua(Gannan Medical University,the First Affiliated Hospital;Gannan Medical University,School of Basic Medicine,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院第一附属医院肾内科 [2]赣南医学院基础医学院分析实验室,江西赣州341000

出　　处：《赣南医学院学报》2020年第8期848-852,共5页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：IgA肾病(IgA nephropathy,IgAN)是最常见的原发性肾小球肾炎,以系膜区IgA或IgA免疫复合物沉积为主要表现。参与的主要免疫细胞膜分子有转铁蛋白受体(transferrin receptor,CD71)、转谷氨酰胺酶2(transglutaminase 2,TG2)和可溶性CD89(soluble CD89,sCD89)等,它们在IgAN发病中占有非常重要的地位。同时,新的研究认为系膜细胞的激活可能并不是由半乳糖缺乏的IgA1及其复合物所造成的。因此,深入研究IgAN相关的免疫细胞膜分子及系膜细胞激活方式对于阐明该病的发病机制及靶向治疗具有非常重要的意义。IgA nephropathy(IgAN)is the most common primary glomerulonephritis,mainly manifested by the deposition of IgA or IgA complexes in mesangial region.The immune cell membrane molecules:transferrin receptor(CD71),transglutaminase 2(TG2)and soluble CD89(sCD89)play important roles in the pathogenesis of IgAN.At the same time,it is suggested that the activation of mesangial cells may not be galactose deficient IgA1 or its immune complexes.Therefore,in-depth study of igan-related activation modes of immune cell membrane molecules and mesangial cells is of great significance to elucidate the pathogenesis and targeted therapy of this disease.

关 键 词：IGA肾病 转铁蛋白受体 转谷氨酰胺酶2 可溶性CD89 系膜细胞 

分 类 号：R692.31[医药卫生—泌尿科学]