热休克蛋白47与哺乳动物生殖  

Heat shock protein 47 and mammalian reproduction

作　　者：高辉 王艺琛 张昌军 刁红录 GAO Hui;WANG Yi-chen;ZHANG Chang-jun;DIAO Hong-lu(Reproductive Medicine Center,Renmin Hospital,Hubei University of Medicine,Shiyan 442000;Biomedical Research Institute,Hubei University of Medicine,Shiyan 442000;Hubei Clinical Research Center for Reproductive Medicine,Shiyan 442000;Biomedical Engineering College,Hubei University of Medicine,Shiyan 442000)

机构地区：[1]十堰市人民医院(湖北医药学院附属人民医院)生殖医学中心,十堰442000 [2]湖北医药学院生物医药研究院,十堰442000 [3]湖北省生殖医学临床医学研究中心,十堰442000 [4]湖北医药学院生物医学工程学院,十堰442000

出　　处：《生殖医学杂志》2020年第10期1393-1398,共6页Journal of Reproductive Medicine

基　　金：国家自然科学基金(31671565);湖北医药学院生物医药研究院PI项目(HBMUPI201802);湖北医药学院研究生科技创新项目(YC2019002)。

摘　　要：热休克蛋白47(HSP47)是一种定位在内质网上的胶原蛋白特异性分子伴侣,由SERPINH1基因编码,属于丝氨酸蛋白酶抑制剂超家族。HSP47与具有三螺旋结构的前胶原蛋白结合促进胶原蛋白的成熟。当HSP47生成障碍时,会导致基底膜不连续的断裂从而致使胚胎死亡,同时HSP47在器官发生、细胞分化、性腺的发育、维持胎膜的正常功能方面具有十分重要的意义。本文将对HSP47在哺乳动物生殖领域的最新研究进展进行综述。Heat shock protein 47(HSP47)is a collagen-specific molecular chaperone localized in the endoplasmic reticulum,encoded by the SERPINH1 gene,and belonging to the serine protease inhibitor superfamily.HSP47 binds to the triple helix procollagen to promote collagen maturation.When the formation of HSP47 is impaired,it will lead to the discontinuous rupture of the basement membrane,resulting in the death of the embryo.Meanwhile,HSP47 is of great significance in organogenesis,cell differentiation,gonad development,and maintenance of the normal function of the fetal membrane.In this paper,the latest research progress on HSP47 in mammalian reproduction is reviewed.

关 键 词：热休克蛋白47 胶原蛋白 胚胎发育 性腺 胎膜 

分 类 号：R715.5[医药卫生—妇产科学]