肾病综合征患者血清IgG、IgM、IgA水平变化及临床意义  

Changes of serum IgG,IgM,IgA levels in patients with nephrotic syndrome and their clinical significance

作　　者：杨全[1] 赵蓉苑 李跃昌 曾宇鹏 YANG Quan;ZHAO Rongyuan;LI Yuechang;ZENG Yupeng(Department of Nephrology,Langzhong People􀆳s Hospital,Langzhong,Sichuan,China,637400)

机构地区：[1]四川省阆中市人民医院肾病内科,四川阆中637400

出　　处：《分子诊断与治疗杂志》2020年第9期1152-1154,1162,共4页Journal of Molecular Diagnostics and Therapy

基　　金：四川省卫生厅科研基金(170190)。

摘　　要：目的探讨肾病综合征(NS)患者血清免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)水平变化及临床意义。方法分析2018年3月到2020年3月本院收治的120例NS患者(NS组)的病例资料,另选取120例同期体检健康者作为健康组,比较两组血清IgG、IgM、IgA水平,分析NS患者血清IgG、IgM、IgA水平与年龄、性别、病理类型的相关性。结果 NS组血清的IgG、IgA水平低于健康组的,IgM水平显著高于健康组,差异均有统计学意义(P<0.05);NS组的女性患者的IgG、IgM水平明显高于男性患者,差异有统计学意义(P<0.05),不同性别患者的血清IgA水平比较差异无统计学意义(P>0.05);不同年龄层NS患者血清IgG、IgM、IgA水平比较差异无统计学意义(P>0.05);IgA肾病组患者血清IgG、IgA水平高于膜性肾病组和其他肾病组,差异均有统计学意义(P<0.05),不同病理类型NS患者血清IgM水平比较差异无统计学意义(P>0.05)。结论 NS患者血清IgG、IgA水平显著降低,IgM水平显著增高,血清免疫球蛋白分类检测对于NS诊断具有重要的潜在应用价值。Objective To explore the changes serum levels of serum immunoglobulin G(IgG),immunoglobulin M(IgM)and immunoglobulin A(IgA)in patients with nephrotic syndrome(NS)and clinical significance. Methods The clinical data of 120 NS patients(NS group)who were admitted to the hospital from March 2018 to March 2020 were analyzed. Another 120 healthy people who underwent physical examination during the same period were enrolled as the healthy group. The serum levels of IgG,IgM and IgA were compared between the two groups. The correlation between the levels of serum IgG,IgM,IgA and age,gender,pathological types in NS patients was analyzed. Results The levels of serum IgG and IgA in the NS group were lower than those in the healthy group,while IgM was higher than that in the healthy group(P<0.05). In the NS group,the levels of IgG and IgM in females were significantly higher than those in males(P<0.05),while there was no difference in serum IgA level in patients with different genders(P>0.05). There were no significant differences in the levels of serum IgG,IgM and IgA among NS patients at the different age groups(P>0.05). The levels of serum IgG and IgA in the IgA nephropathy group were higher than those in the membranous nephropathy group and other nephropathy groups(P<0.05). There was no significant difference in serum IgM level among NS patients with different pathological types(P>0.05). Conclusion Serum IgG and IgA levels in NS patients are significantly reduced,and IgM levels are significantly increased. Serum immunoglobulin classification detection has important potential application value for the diagnosis of NS.

关 键 词：肾病综合征 免疫球蛋白 膜性肾病 IGG 

分 类 号：R692[医药卫生—泌尿科学]