单核细胞高密度脂蛋白比值、血清尿酸水平与冠心病患者冠脉狭窄程度的相关性  

Correlation between the ratio of monocyte high-density lipoprotein,serum uric acid level and coronary artery stenosis in patients with coronary heart disease

作　　者：郎勇 冉迅[1] 屈模英[1] LANG Yong;RAN Xun;QU Moying(Department of Cardiology,Shangjin hospital,West China Hospital Of Sichuan University,Sichuan,Chengdu,China,610000)

机构地区：[1]四川大学华西医院上锦医院心内科,四川成都610000

出　　处：《分子诊断与治疗杂志》2020年第9期1184-1186,1191,共4页Journal of Molecular Diagnostics and Therapy

基　　金：四川省卫生和计划生育委员会科研课题(16PJ305)。

摘　　要：目的研究单核细胞高密度脂蛋白比值、血清尿酸水平与冠心病患者冠脉狭窄程度的相关性。方法选取2017年1月至2018年1月于本院接冠心病患者122例,根据Gensini评分将122例分为轻度组(Gensini评分<40)59例和重度组63例(Gensini评分≥40)分别比较两组患者甘油三酯(TG)总胆固醇(TC)低密度脂蛋白-胆固醇(LDL)高密度脂蛋白-胆固醇(HDL)水平;分别比较两组患者单核细胞(MONO)数目、白细胞数目(WBC)和淋巴细胞计数(LYMP)并比较两组单核细胞高密度脂蛋白比值(MHR);分别比较两组患者MHR、血清UA水平;分析Gensini评分与MHR、血清UA水平的相关性。结果相比轻度组,重度组LDL水平、MONO水平、WBC水平、MHR、血清UA水平均显著升高(P<0.05);相比轻度组,重度组HDL水平显著降低(P<0.05);相比轻度组,重度组TG水平、TC水平和LYMP差异无统计学意义(P>0.05);MHR和血清UA均与冠状动脉狭窄程度呈正相关(r=0.557,P<0.001;r=0.341,P<0.001)。结论 MHR和血清UA水平会随着冠心病患者冠脉狭窄程度升高而升高且呈正相关。Objective To study the correlation between monocyte to high-density lipoprotein ratio(MHR),serum uric acid(UA)level and coronary stenosis in patients with coronary heart disease(CHD).Methods From January 2017 to January 2018,122 CHD patients who were admitted to the hospital were enrolled. According to different Gensini scores,they were divided into the mild group(Gensini score lower than40 points,59 cases)and the severe group(Gensini score not lower than 40 points,63 cases). The levels of triglyceride(TG),total cholesterol(TC),low-density lipoprotein-cholesterol(LDLC)and high-density lipoprotein-cholesterol(HDLC) were measured and compared between the two groups. The monocyte(MONO)count,white blood cell count(WBC),lymphocyte count(LYMP)and monocyte to high-density lipoprotein ratio(MHR)were compared between the two groups. MHR and serum UA level were compared between the two groups. The correlation between Gensini score and MHR,serum UA level was analyzed.Results Compared with the mild group,LDL,MONO,WBC,MHR and serum UA level were significantly increased(P<0.05),while HDL level was significantly decreased in the severe group(P<0.05). Compared with the mild group,the differences in TG,TC and LYMP were not significantly significant in the severe group(P>0.05). MHR and serum UA were positively correlated with coronary stenosis(r=0.557,P<0.001. r=0.341,P<0.001). Conclusion MHR and serum UA levels will increase with the increase of coronary artery stenosis in patients with coronary heart disease and are positively correlated.

关 键 词：冠心病 高密度脂蛋白 血清尿酸 单核细胞 

分 类 号：R541.4[医药卫生—心血管疾病]