NH2-MCM-41的改性及其pH 响应性释药的研究  

Study on modification of NH2-MCM-41 and its pH-responsive drug release

作　　者：徐彦芹[1] 秦钊 王烨 曹渊[1] 陈昌国[1] 王丹[2] XU Yanqin;QIN Zhao;WANG Ye;CAO Yuan;CHEN Changguo;WANG Dan(School of Chemistry and Chemical Engineering,Chongqing University,Chongqing 401331,China;State Key Laboratory of Coal Mine Disaster Dynamics and Control,Chongqing University,Chongqing 401331,China)

机构地区：[1]重庆大学化学化工学院,重庆401331 [2]重庆大学煤矿灾害动力学与控制国家重点实验室,重庆401331

出　　处：《化工学报》2020年第10期4783-4791,共9页CIESC Journal

基　　金：国家自然科学基金项目(21978027)。

摘　　要：采用正硅酸乙酯(TEOS)和3-氨丙基三乙氧基硅烷(APTES)通过共缩聚法合成介孔二氧化硅(MCM-41)。首先对其氨基修饰,再通过有机合成接枝—R基团(—R:—CHO、—OH、—CH3、—COOH),制备得到Me-Ph-NH-MCM-41、OHC-Ph-NH-MCM-41、HO-Ph-NH-MCM-41、HOOC-Ph-NH-MCM-41四种不同的药物载体。利用FT-IR、Zeta电位、XRD和SEM对其结构和形貌表征,结果表明NH2-MCM-41改性成功。以罗丹明B(RhB)为模型进行载药性能测试,并考察了此释药系统在模拟不同pH的体液下的敏感释药行为,同时探究了不同—R基团对释药的影响。结果显示,四种载体在中性条件下几乎不发生药物释放,通过改变环境体系pH可以有效控制药物释放,其释药行为可以用Korsmeyer-Peppas动力学模型来描述。实验表明,释药量:RhB@HOOCPh-NH-MCM-41>RhB@OHC-Ph-NH-MCM-41>RhB@HO-Ph-NH-MCM-41>RhB@Me-Ph-NH-MCM-41,不同—R基团的药物载体的pH响应性不同,其中RhB@HOOC-Ph-NH-MCM-41释药量在pH=1.2时可达57.87%,在用于药物智能控释材料方面具有一定的应用潜力。Mesoporous silica(MCM-41)was synthesized by copolycondensation of tetraethoxysilane(TEOS)and 3-aminopropyltriethoxysilane(APTES).Firstly,it was modified with amino group.Then,four different drug carriers,Me-Ph-NH-MCM-41,OHC-Ph-NH-MCM-41,HO-Ph-NH-MCM-41,and HOOC-Ph-NH-MCM-41,were synthesized by grafting—R group(—R:—CHO,—OH,—CH3,—COOH),respectively.FT-IR,SEM,Zeta potential,and XRD were used to characterize its structure and morphology,indicating the successful synthesis of modified MCM-41.Rhodamine B(RhB)was used as a model for drug loading performance testing and the sensitive drug release behavior of this drug release system under different pH simulated humors was investigated.The effects of different—R groups on drug release were also explored.The results show that the four carriers hardly release drugs under neutral conditions.The drug release can be effectively controlled by changing the pH of the environmental system.The drug release behavior can be described by the Korsmeyer-Peppas kinetic model.The experiment showed that the drug release amount:RhB@HOOC-Ph-NH-MCM-41>RhB@OHC-Ph-NH-MCM-41>RhB@HO-Ph-NH-MCM-41>[e-mail] pH-response of drug carriers with different—R groups was different,and the drug release amount of RhB@HOOC-Ph-NH-MCM-41 reached 57.87%at pH=1.2,which has some potential applications in intelligent controlled release materials of drugs.

关 键 词：二氧化硅 合成 控制 载体 动力学模型 

分 类 号：O643.36[理学—物理化学]