川芎嗪改善高血压血管重构的研究进展  

Research advances in the improvement of vascular remodeling in hypertensive patients with tetramethylpyrazine

作　　者：李芳芳 张琪[1] LI Fangfang;ZHANG Qi(Basic Medical College,Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学基础医学院,咸阳712046

出　　处：《西北药学杂志》2020年第5期785-788,共4页Northwest Pharmaceutical Journal

基　　金：国家自然科学基金项目(编号:81470543,81774295)。

摘　　要：目的为川芎嗪的进一步研究提供参考,为其在高血压血管重构方面的研究及治疗提供科学依据。方法在中国知网和PubMed 2个数据库中检索有关川芎嗪改善高血压血管重构的多种作用机制的相关研究文献,并进行综述。结果川芎嗪改善高血压血管重构的作用机制主要集中在:改善血管内皮功能障碍、抑制平滑肌细胞增殖与迁移、改善血液循环、延缓外膜成纤维细胞的表型转化和平衡细胞外基质的合成与降解。结论川芎嗪改善高血压血管重构的作用机制集中在小样本的临床研究和实验研究中,针对这些作用机制的研究尚且不足,后期应加强有关川芎嗪改善高血压血管重构的作用机制方面的大样本相关研究。Objective To provide reference for further research of tetramethylpyrazine and provide scientific basis for the study and treatment of hypertension in vascular remodeling.Methods The relevant research literatures on the mechanisms of tetramethylpyrazine in improving vascular remodeling in hypertension were searched from China Knowledge Network and PubMed databases,then summarized.Results The mechanisms of tetramethylpyrazine in improving vascular remodeling in hypertension mainly focuses on:improving vascular endothelial dysfunction,inhibiting the proliferation and migration of smooth muscle cells,improving blood circulation,delaying the phenotypic transformation of outer membrane fibroblasts,and balancing the synthesis and degradation of extracellular matrix.Conclusion The mechanism of tetramethylpyrazine in improving vascular remodeling in hypertension is mainly focused on small sample clinical and experimental studies,and the researches on these mechanisms are still insufficient.Later,the research on the mechanism of tetramethylpyrazine in improving vascular remodeling in hypertension with large samples should be strengthened.

关 键 词：川芎嗪 血管重构 平滑肌细胞 成纤维细胞 细胞外基质 

分 类 号：R972[医药卫生—药品]