饮用水消毒副产物基因毒性与致癌性研究进展  

A Review on the Genotoxicity and Carcinogenicity of Disinfection By-Products in Drinking Water

作　　者：洪涵璐 赵伟[1] 尹金宝 HONG Han-lu;ZHAO Wei;YIN Jin-bao(State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China)

机构地区：[1]污染控制与资源化研究国家重点实验室,南京大学环境学院,江苏南京210023

出　　处：《环境监控与预警》2020年第5期36-48,共13页Environmental Monitoring and Forewarning

基　　金：国家自然科学基金青年基金资助项目(21806079)。

摘　　要：简述了饮用水消毒副产物(DBPs)的基因毒性与致癌性的研究进展。从Ames试验、SOS/umu试验、彗星试验、微核试验及一些新颖的致突变试验结果对DBPs基因的毒性,以及从毒理学实验、流行病学研究和致癌风险评估3个方面对DBPs的致癌性进行了分析和总结,以期为今后饮用水DBPs毒性效应及其致毒机理研究提供参考,进而促进饮用水质量管理与立法的发展。This study briefly reviews the research advance on the genotoxicity and carcinogenicity of Disinfection by-poroducts(DBPs)in drinking water.This article summarizes the genotoxicity of DBPs from the results of the Ames test,SOS/umu test,comet test,micronucleus test,and some novel mutagenic tests;the carcinogenicity of DBPs is analyzed from three aspects:toxicology test,epidemiological research,and carcinogenic risk assessment.The review provides references for future research on the toxic effects and mechanisms of DBPs in drinking water,and promotes the development of drinking water quality management and legislation.

关 键 词：饮用水 消毒副产物 基因毒性 致癌性 

分 类 号：R123.1[医药卫生—环境卫生学]