生物法制备丁二酸的研究及产业化进展  

Progress in industrialization on succinic acid production by fermentation

作　　者：万屹东 高有军 马江锋 WAN Yidong;GAO Youjun;MA Jiangfeng(Changmao Biochemical Engineering Company Limited,Changzhou 213034,China;Jiangsu Biochemical Chirality Engineering Technology Research Center,Changzhou 213034,China;College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211800,China)

机构地区：[1]常茂生物化学工程股份有限公司,江苏常州213034 [2]江苏省生化手性工程技术研究中心,江苏常州213034 [3]南京工业大学生物与制药工程学院,江苏南京211800

出　　处：《生物加工过程》2020年第5期583-591,630,共10页Chinese Journal of Bioprocess Engineering

基　　金：江苏省重大科技项目(BE2016389)。

摘　　要：丁二酸是重要的C4平台化合物,采用生物发酵法、以可再生生物质资源和温室气体CO2等为原料的制备路线具有显著的优势,近年来成为国内外研究热点。目前已经有多个生物基丁二酸的产业化生产装置,但其制造成本仍然比石油基丁二酸的要高。鉴于此,本文中,笔者针对国内外生物基丁二酸研究和生产现状,从生产菌株、底物碳源、生产工艺三方面进行综述,发现现有微生物发酵法生产丁二酸仍然存在诸多技术屏障,生产的经济性有待进一步提高,并提出了未来几条经济性较高的丁二酸合成路线。Succinate is an important chemical in C4 platform.Fermentation production of succinate has obvious advantages due to the use of renewable resources and fixation of greenhouse-gas CO2,gaining worldwide attention for the past few years.Recently,several industrial facilities have been established although the cost is still higher than that of petroleum-based production.Based on that,this review focuses on strains,substrates,processes to summarize the progress of research and industrialization on succinate production by fermentation,indicating that there are still several technical barriers in bio-based production of succinate,and the production economy needs to be further improved.Finally,several economical synthesis routes of succinate are proposed.

关 键 词：丁二酸 二氧化碳 可再生资源 生物制造 

分 类 号：TQ225.144[化学工程—有机化工]