长期冻存胚胎复苏移植后的妊娠结局和安全性研究  

Pregnancy outcome and safety of frozen-thaw embryo transfer after long-term cryopreservation

作　　者：卢娜[1] 窦倩[1] 禹果[1] 马丽影[1] 谭丽[1] Lu Na;Dou Qian;Yu Guo;Ma Liying;Tan Li(Reproductive Center,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450003,China)

机构地区：[1]郑州大学第二附属医院生殖中心,450003

出　　处：《中国实用医刊》2020年第15期1-4,共4页Chinese Journal of Practical Medicine

基　　金：河南省科技厅科技攻关项目(142300410240,162102310207)。

摘　　要：目的:研究人类胚胎冷冻保存时间超过6年复苏移植后胚胎的存活率、妊娠结局及对母体和子代安全性的影响。方法:回顾性分析2008年1月至2012年12月在郑州大学第二附属医院生殖中心接受辅助生殖技术助孕并有冻存胚胎患者的资料,根据冻存时间是否超过6年分为长期冻存组(84例)和对照组(278例)。比较两组的临床资料,复苏胚胎的存活率,移植后的种植率、临床妊娠率、流产率、异位妊娠率、活产率以及妊娠期间母体并发症发生率和子代安全性。结果:长期冻存组复苏移植时女方年龄高于对照组(P<0.05),两组间胚胎存活率比较差异未见统计学意义(P>0.05),但胚胎完全存活率低于对照组(52.49%比67.72%),P<0.05。两组种植率、临床妊娠率、流产率和活产率比较差异未见统计学意义(P>0.05)。妊娠期并发症和子代安全性比较差异未见统计学意义(P>0.05)。结论:冻存6年以上的胚胎尚可获得良好的妊娠结局,但需考虑母体年龄增长可能引起的妊娠及围生期风险。Objective To study the effects of long-term cryopreservation(more than 6 years)on the survival rate,pregnancy outcome,and safety of the mother and baby after frozen-thaw embryo transfer.Methods The data of the patients who received assisted reproductive technology in the Reproductive Center of the Second Affiliated Hospital of Zhengzhou University and provided embryos for cryopreservation from January 2008 to December 2012 were retrospectively analyzed.All patients were divided into long-term cryopreservation group(84 embryos preserved more than 6 years)and control group(278 embryos preserved less than 6 years).The differences between the two groups in clinical records,rate of survival frozen-thaw embryos,implantation rate after transplantation,pregnancy rate,abortion rate,ectopic pregnancy rate,live baby rate,complication rate during pregnancy and the safety of babies were compared.Results The age of mother in long-term cryopreservation group were significant older than that in control group during frozen-thaw embryo transfer(P<0.05).While there was no significant difference between the two groups in the survival rates of embryos(P>0.05),however,the completely survival rate of embryos of long-term cryopreservation group was significant lower than that of control group(52.49%vs.67.72%,P<0.05).In addition,there were no significant differences between the two groups in the rates of transplant,clinical pregnancy,abortion,live baby(P>0.05).And there was no significant difference in complications during pregnancy,and safety of babies between the two groups(P>0.05).Conclusions A good clinical pregnancy could be expected with the long-term cryopreserved embryos(more than 6 years).However,due to the increasing age of mother,the potential risks in pregnancy and perinatal period need to be taken into account.

关 键 词：胚胎 长期冻存 复苏移植 临床结局 

分 类 号：R714.8[医药卫生—妇产科学]