金黄色葡萄球菌毒力因子的研究进展  

Advance in study of Staphylococcus aureus virulence factors

作　　者：李雅倩 胡同平[1] LI Ya-qian;HU Tong-ping(The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Secience and Technology,Baotou,Inner Mongolia 014010,China)

机构地区：[1]内蒙古科技大学包头医学院第一附属医院检验科,内蒙古包头014010

出　　处：《中华医院感染学杂志》2020年第17期2712-2716,共5页Chinese Journal of Nosocomiology

基　　金：内蒙古自治区自然科学基金资助项目[2016MS(LH)0824];包头市医药卫生科技计划基金资助项目(wsjj2013080);包头医学院科学研究基金项目-扬帆计划(BYJJ-YF-201691)。

摘　　要：金黄色葡萄球菌(Staphylococcus aureus,SA)是引起多种临床感染的常见致病菌,是社区获得性感染及医院获得性感染的常见病原菌.金黄色葡萄球菌的高致病性及其快速传播性与其分泌的毒力因子有很大的相关性.通过对金黄色葡萄球菌毒力因子的研究,可以为其引起的疾病开创新的治疗方向.近年来在金黄色葡萄球菌毒力因子的研究上取得了重大进展.本文就金黄色葡萄球菌成孔毒素、表皮剥脱毒素和超级抗原的致病机制及其研究现状作一综述.Staphylococcus aureus(SA)is a common pathogen that causes a variety of clinical infections and is a common pathogen of community-acquired infections and hospital-acquired infections.The high pathogenicity of S.aureus and its rapid spread are highly correlated with the virulence factors.Through the study of the virulence factors of aureus,it can open a new therapeutic direction for the diseases caused by it.In recent years,significant progress has been made in the study of virulence factors of S.aureus.The pathogenic mechanisms of S.aureus pore-forming toxin,exfoliation toxin and superantigen and its research status were reviewed in the article.

关 键 词：金黄色葡萄球菌 成孔毒素 表皮剥脱毒素 超级抗原 ε-毒素 

分 类 号：R378.11[医药卫生—病原生物学]