川崎病患儿并发冠状动脉扩张的临床特点及危险因素分析  

Analysis of clinical characteristics and risk factors of coronary artery ectasia in children with Kawasaki disease

作　　者：王坤 孔小行[1] 成芳芳[1] 田健美[1] WANG Kun;KONG Xiaoxing;CHENG Fangfang;TIAN Jianmei(Infectious Diseases Department,Children's Hospital of Soochow University,Suzhou 215000,China)

机构地区：[1]苏州大学附属儿童医院感染性疾病科,江苏苏州215000

出　　处：《临床医学研究与实践》2020年第29期7-9,共3页Clinical Research and Practice

摘　　要：目的探讨川崎病(KD)患儿并发冠状动脉扩张(CAE)的临床特点及危险因素。方法回顾性分析383例KD患儿的临床资料,其中冠状动脉未扩张患儿(NCAE组)196例,冠状动脉扩张(CAE组)187例。分析KD患儿并发CAE的危险因素。结果单因素分析结果显示,CAE组的WBC、PLT、N、CD3+CD4+、CRP、ESR、PCT均高于NCAE组,而月龄、Hb、CD3+CD8+、C4、IgG均低于NCAE组(P<0.05)。Logistic回归分析结果显示,PLT、CRP、PCT是KD患儿发生CAE的独立危险因素(P<0.05)。经ROC曲线下面积计算得出PLT、CRP、PCT及三项指标联合检测(预测概率)的临界值分别为487.5×109/L、73.125 mg/L、0.695 ng/mL及0.551。结论当KD患儿临床指标中出现PLT≥487.5×109/L、CRP≥73.125 mg/L、PCT≥0.695 ng/mL或预测概率≥0.551中任意一种情况时,均提示发生CAE的可能性增加。Objective To explore the clinical characteristics and risk factors of coronary artery ectasia(CAE)in children with Kawasaki disease(KD).Methods The clinical data of 383 children with KD were retrospectively analyzed,including 196 children without CAE(NCAE group)and 187 patients with CAE(CAE group).The risk factors of CAE in KD children were analyzed.Results Univariate analysis showed that WBC,PLT,N,CD3+CD4+,CRP,ESR and PCT in the CAE group were higher than those in the NCAE group,while month age,Hb,CD3+CD8+,C4 and IgG in the CAE group were lower than those in the NCAE group(P<0.05).Logistic regression analysis showed that PLT,CRP and PCT were independent risk factors of CAE in KD children(P<0.05).According to the area under ROC curve,the critical values of PLT,CRP,PCT and three indicators combined detection(predicted probability)were 487.5×109/L,73.125 mg/L,0.695 ng/mL and 0.551,respectively.Conclusion When PLT≥487.5×109/L,CRP≥73.125 mg/L,PCT≥0.695 ng/mL or prediction probability≥0.551 appears in the clinical indicators of children with KD,the possibility of CAE increase.

关 键 词：川崎病 冠状动脉扩张 临床特点 危险因素 

分 类 号：R725.4[医药卫生—儿科]