葛根注射液辅助治疗对急性心肌梗死患者心功能及血浆ET-1、BNP水平的影响  

Effect of Puerarin Injection on Heart Function and Levels of ET-1 and BNP in Plasma in Patients with Acute Myocardial Infarction

作　　者：蔡晓航[1] 李征[1] 马金霞[1] CAI Xiaohang;LI Zheng;MA Jinxia

机构地区：[1]南阳市第一人民医院,河南南阳473000

出　　处：《新中医》2020年第17期55-57,共3页New Chinese Medicine

摘　　要：目的:观察葛根注射液辅助治疗对急性心肌梗死患者心功能及血浆内皮素-1(ET-1)、脑钠肽(BNP)水平的影响。方法:选取94例急性心肌梗死患者为研究对象,按随机数字表法分为观察组和对照组各47例。对照组行常规溶栓、经皮冠脉介入术(PCI)治疗,PCI术后给予阿司匹林肠溶片治疗,观察组在对照组基础上给予葛根注射液治疗,治疗7周。比较2组临床疗效及治疗前后心功能指标,血浆ET-1、血浆BNP水平。结果:观察组总有效率为91.49%,对照组总有效率为82.98%,2组比较,差异无统计学意义(χ~2=1.529,P>0.05)。治疗后,2组左室射血分数(LVEF)、心室短轴缩短率(FS)均较治疗前升高(P<0.05),左室舒张末期内径(LVDd)均较治疗前缩小(P<0.05);观察组LVEF、FS均高于对照组(P<0.05),LVDd小于对照组(P<0.05)。治疗后,2组血浆ET-1、BNP水平均较治疗前下降(P<0.05),观察组血浆ET-1、BNP水平均低于对照组(P<0.05)。结论:葛根注射液辅助治疗急性心肌梗死,可以改善患者的心功能,降低其血浆ET-1及BNP水平。Objective:To observe the effect of puerarin injection on heart function and levels of endothelin-1(ET-1) and brain natriuretic peptide(BNP) in plasma in patients with acute myocardial infarction. Methods:A total of 94 cases of patients with acute myocardial infarction were selected as the study objects,and were divided into the observation group and the control group according to the random number table method,47 cases in each group. The control group was treated with routine thrombolysis and percutaneous coronary intervention(PCI), followed by aspirin enteric-coated tablets, and the observation group was additionally treated with puerarin injection based on the treatment of the control group. Both groups were treated for seven weeks. The heart function indexes and levels of ET-1 and BNP in plasma before and after treatment as well as the clinical effect in the two groups were compared. Results:The total effective rate was 91.49% in the observation group and 82.98% in the control group;there was no significant difference between the two groups(χ~2=1.529,P>0.05).After treatment, the left ventricular ejection fraction(LVEF) and fraction shortening(FS) in the two groups were increased when compared with those before treatment(P<0.05),and left ventricular end-diastolic diameter(LVDd) were reduced(P<0.05);LVEF and FS in the observation group were higher than those in the control group(P<0.05),and LVDd was smaller(P<0.05). After treatment,the contents of ET-1 and BNP in plasma in the two groups were decreased when compared with those before treatment(P<0.05),and the contents in the observation group were lower than those in the control group(P<0.05). Conclusion:Puerarin injection in adjuvant treatment for patients with acute myocardial infarction can improve the heart function and reduce the levels of ET-1 and BNP in plasma.

关 键 词：急性心肌梗死 葛根注射液 心功能 内皮素-1 脑钠肽 

分 类 号：R542.22[医药卫生—心血管疾病]