扶正化痰活血方对复发性流产患者孕激素和胰岛素抵抗的影响  

Effect of Fuzheng Huatan Huoxue Prescription on Progesterone and Insulin Resistance in Patients with Recurrent Spontaneous Abortion

作　　者：郝艳云 常文艺 黄芳芳 HAO Yanyun;CHANG Wenyi;HUANG Fangfang

机构地区：[1]济源市妇幼保健院妇科,河南济源45900

出　　处：《新中医》2020年第17期103-106,共4页New Chinese Medicine

摘　　要：目的:观察扶正化痰活血方对复发性流产患者孕激素和胰岛素抵抗的影响。方法:选取复发性流产患者102例,按随机数字表法分为观察组和对照组各51例。对照组给予地屈孕酮治疗,观察组在对照组基础上给予扶正化痰活血方治疗。比较2组临床疗效,检测激素、血糖和血清炎性因子水平。结果:观察组总有效率为82.35%,高于对照组64.71%,差异有统计学意义(P<0.05)。治疗前,2组孕激素(P)、血清绒毛膜促性腺激素(HCG)水平比较,差异无统计学意义(P>0.05)。孕6周时,2组HCG水平较治疗前上升,观察组P、HCG水平高于对照组;孕12周时,2组P、HCG水平较治疗前上升,观察组HCG水平高于对照组;差异均有统计学意义(P<0.05)。治疗前,2组胰岛素抵抗指数(HOMA-IR)、性激素结合球蛋白(SHBG)、血管内皮生长因子(VEGF)、白细胞介素-10 (IL-10)、白细胞介素-17 (IL-17)、干扰素-γ(IFN-γ)水平比较,差异无统计学意义(P>0.05)。治疗后,2组VEGF、SHBG、IL-10水平较治疗前升高,HOMA-IR、IL-17、IFN-γ水平较治疗前下降;且观察组VEGF、SHBG、IL-10水平高于对照组,HOMA-IR、IL-17、IFN-γ水平低于对照组;差异均有统计学意义(P<0.05)。观察组妊娠成功率为86.27%,高于对照组62.75%,差异有统计学意义(P<0.05)。结论:扶正化痰活血方治疗复发性流产疗效显著,可纠正胰岛素抵抗,调节炎性因子水平,提高妊娠成功率。Objective: To observe the effect of Fuzheng Huatan Huoxue prescription on progesterone and insulin resistance in patients with recurrent spontaneous abortion. Methods: A total of 102 cases of patients with recurrent spontaneous abortion were divided into the observation group and the control group according to the random number table method, 51 cases in each group. The control group was treated with dydrogesterone, and the observation group was additionally given Fuzheng Huatan Huoxue prescription based on the treatment of the control group. The clinical effect in the two groups was compared,and the levels of hormones,blood glucose and inflammatory factors in serum were detected.Results:The total effective rate was 82.35% in the observation group and 64.71% in the control group,the difference being significant(P<0.05). Before treatment, there was no significant difference being found in the comparison of the levels of progesterone(P) and human chorionic gonadotropin(HCG) in serum between the two groups(P>0.05). At six weeks of gestation,the HCG levels in the two groups were increased when compared with those before treatment,and the levels of P and HCG in the observation group were higher than those in the control group;at 12 weeks of gestation,the levels of P and HCG in the two groups were increased when compared with those before treatment, and the HCG level in the observation group was higher than that in the control group,differences being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of insulin resistance index(HOMA-IR),sex hormone binding globulin(SHBG), vascular endothelial growth factor(VEGF), interleukin-10(IL-10), interleukin-17(IL-17) and interferon-γ(IFN-γ) between the two groups(P>0.05). After treatment,the levels of VEGF,SHBG and IL-10 in the two groups were increased when compared with those before treatment,and the levels of HOMA-IR,IL-17 and IFN-γ were decreased;the levels of VEGF,SHBG and IL-10 in the observation group we

关 键 词：复发性流产 扶正化痰活血方 孕激素 血清绒毛膜促性腺激素 胰岛素抵抗指数 炎性因子 

分 类 号：R714.21[医药卫生—妇产科学]