达泊西汀联合行为、心理咨询疗法治疗原发性早泄的临床分析  

Priligy combined with behavioral therapy and psychological counseling for primary premature ejaculation

作　　者：蔡东洋 杨永平 武娇 徐胜旗 郭凯敏[1] 王洪亮[1] 李付彪[1] CAI Dong-yang;YANG Yong-ping;WU Jiao;XU Sheng-qi;GUO Kai-min;WANG Hong-liang;LI Fu-biao(Department of Andrology,The First Hospital of Jilin University,The Second Hospital of Jilin University,Changchun,Jilin 130000,China;Department of General Surgery,The Second Hospital of Jilin University,Changchun,Jilin 130000,China)

机构地区：[1]吉林大学第一医院男科,吉林长春130000 [2]吉林大学第二医院普外科,吉林长春130000

出　　处：《中华男科学杂志》2020年第7期611-615,共5页National Journal of Andrology

摘　　要：目的:观察研究达泊西汀(必利劲)联合行为、心理咨询疗法治疗原发性早泄(PE)的临床效果。方法:将2017~2018年度我院男科门诊202例诊断为原发性PE患者,随机分成对照组和试验组,其中对照组(100例)单纯给予达泊西汀治疗,30 mg,性生活前1~3 h服用;试验组(102例)给予达泊西汀联合行为、心理咨询疗法治疗,每月1次,每次30 min,共2次,达泊西汀服用方法相同。两组治疗时间均为2个月,期间分别在服药1个月、2个月进行2次随访测评,以早泄情况(PEP)问卷各项得分情况评估早泄治疗效果。结果:治疗1个月后两组患者射精控制评分改善不明显(P>0.05),其他3项评分略改善(P<0.05);治疗2个月后,各PEP评分指标均明显改善(P<0.05)。治疗2个月后,试验组射精控制评分(2.73±0.95)、射精相关个人痛苦情况评分(2.97±1.07)、对性生活的满意度评分(3.19±1.03)、射精相关人际关系困扰评分(2.85±0.99)明显高于对照组(P均<0.05)。两组不良事件发生率无明显统计学意义(对照组:20.0%,试验组:21.6%,P>0.05),均在24 h内症状缓解。结论:达泊西汀联合行为、心理咨询疗法治疗效果优于达泊西汀单独疗法。此外行为疗法可增加性生活的趣味性,有利于增加伴侣间的亲密感,而非药物作用,部分患者甚至可达到临床治愈的目的,值得临床推广应用。Objective:To observe the clinical effect of priligy(dapoxetine hydrochloride)combined with behavioral therapy and psychological counseling in the treatment of primary premature ejaculation(PPE).Methods:A total of 202 PPE patients diagnosed from 2017 to 2018 were randomized into a control(n=100)and an experimental group(n=102),the former treated with oral priligy at 30 mg 1-3 hours before anticipated sexual activity,and the latter by the same medication combined with 30-minute behavioral therapy and psychological counseling once a month for two times.The therapeutic effects were evaluated according to the Premature Ejaculation Profile(PEP)scores of the patients at 1 and 2 months of treatment.Results:After 1 month of treatment,both groups of the patients showed significant improvement,as compared with the baseline,in the PEP scores on personal distress related to ejaculation(P<005),interpersonal difficulty related to ejaculation(P<0.05)and satisfaction with sexual intercourse(P<0.05)but not on perceived control over ejaculation(P>0.05).At 2 months,however,the patients’scores on all the four PEP items were dramatically improved,even more significantly in the experimental than in the control group,as on perceived control over ejaculation(2.73±0.95 vs 2.22±0.68,P<0.05),personal distress related to ejaculation(2.97±1.07 vs 2.57±0.69,P<0.05),interpersonal difficulty related to ejaculation(3.19±1.03 vs 2.77±0.69,P<005)and satisfaction with sexual intercourse(2.85±0.99 vs 2.35±0.63,P<0.05).There was no statistically significant difference in the incidence rate of adverse events between the experimental and control groups(21.6%vs 20.0%,P>0.05),and all the symptoms were relieved within 24 hours.Conclusion:Priligy combined with behavioral therapy and psychological counseling is more effective than priligy alone in improving the sexual function of PPE patients,raise their interest in sexual life and increase the intimacy between the partners,and can even achieve clinical cure in some patients.

关 键 词：原发性早泄 行为疗法 心理咨询疗法 达泊西丁(必利劲) 

分 类 号：R698[医药卫生—泌尿科学]