156例肾虚型与非肾虚型勃起功能障碍患者血液生化指标比较分析  

Blood biochemical indexes in ED patients with kidney deficiency or non-kidney deficiency:A comparative analysis of 156 cases

作　　者：王瑞[1] 张天标[1] 吕坤龙 郑涛[1] 殷正伟 郝亚伟[1] 南永浩 张卫星[1] WANG Rui;ZHANG Tian-biao;Lü Kun-long;ZHENG Tao;YIN Zheng-wei;HAO Ya-wei;NAN Yong-hao;ZHANG Wei-xing(Department of Andrology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州大学第一附属医院男科,河南郑州450000

出　　处：《中华男科学杂志》2020年第7期645-649,共5页National Journal of Andrology

摘　　要：目的:对各型肾虚及非肾虚型勃起功能障碍(ED)患者血液生化指标进行测定,确定各型肾虚的血液生化特点。方法:收集2018年5~7月在男科就诊的156例ED患者的临床资料,根据中医辨证分为肾阳虚组(48例)、肾阴虚组(34例)、肾阴阳两虚组(36例)及非肾虚对照组(38例),检测血液生化指标:睾酮(T),雌二醇(E2),皮质醇(CORT),促甲状腺激素(TSH),游离型甲状腺素(FT4),游离型三碘甲状腺原氨酸(FT3),一氧化氮(NO),一氧化氮合酶(NOS),诱导型一氧化氮合酶(iNOS)。结果:4组患者平均年龄、病程、国际勃起功能问卷-5评分(IIEF-5)、勃起硬度评分(EHS)无显著差异;4组患者CORT、FT3、iNOS水平两两比较显示肾阴虚组CORT水平[(121.78±41.87)μg/L]高于对照组[(87.97±45.59)μg/L,P=0.002],肾阳虚组FT3水平[(5.11±0.54)pmol/L]低于对照组[(5.44±0.38)pmol/L,P=0.008],肾阴虚组iNOS水平[(14.42±2.49)U/ml]高于对照组[(12.71±2.58)U/ml,P=0.039]和肾阳虚组[(13.05±2.17)U/ml,P=0.049],其余各组之间各指标无显著差异。结论:ED患者不同肾虚证型之间存在血液生化指标差异,发现肾虚证型之间的生化差异,有助于探明ED患者中医肾虚证型的生物基础。Objective:To analyze the blood biochemical characteristics of the ED patients with different types of kidney deficiency or non-kidney deficiency.Methods:We reviewed the clinical data on 156 ED patients treated in our Department of Andrology from May to July 2018 and,according to the traditional Chinese medicine(TCM)syndromes,divided them into four groups:kidney-yang deficiency(n=48),kidney-yin deficiency(n=34),kidney-yin+yang deficiency(n=36)and non-kidney deficiency control(n=38).We obtained and compared their blood biochemical indexes,including the levels of testosterone(T),estradiol(E2),cortisol(CORT),thyroid stimulating hormone(TSH),free thyroxine(FT4),free triiodothyronine(FT3),nitric oxide(NO),total nitric oxide synthase(tNOS),and inducible nitric oxide synthase(iNOS).Results:There were no statistically significant differences in the mean age,course of disease,IIEF-5 score and erection hardness score(EHS)among the four groups of patients.Pairwise comparison showed that,compared with the non-kidney deficiency controls,the patients in the kidney-yin deficiency group exhibited a dramatically higher level of CORT([87.97±45.59]vs[121.78±41.87]μg/L,P=0.002)and those in the kidney-yang deficiency group a remarkably lower level of FT3([5.44±0.38]vs[5.11±0.54]pmol/L,P=0.008).The iNOS level was significantly higher in the kidney-yin deficiency group(14.42±2.49 U/ml)than in either the control(12.71±2.58 U/ml)(P=0.039)or the kidney-yang deficiency group(13.05±2.17 U/ml)(P=0.049).Conclusion:ED patients with different types of kidney deficiency syndromes have different blood biochemical indexes,which may help clarify the biological basis of the TCM syndromes of kidney deficiency in ED patients.

关 键 词：勃起功能障碍 肾虚 阴阳 一氧化氮合酶 

分 类 号：R698+.1[医药卫生—泌尿科学]