含芳基咪唑并[2,1-b]-1,3,4-噁二唑的微波合成  

MICROWAVE-ASSISTANT SYNTHESIS OF ARYLIMIDAZO[2,1-b]-1,3,4-OXADIAZOLES

作　　者：尹大伟 孙嘉希 刘玉婷 李洁 Yin Dawei;Sun Jiaxi;Liu Yuting;Li Jie(Shaanxi Key Laboratory of Chemical Additives for Industry,College of Chemistry and Chemical Engineering,Shaanxi University of Science&technology,Xi’an 710021,Shaanxi,China;Institute of Frontier Science and technology transfer,Shaanxi University of Science&technology,Xi’an 710021,Shaanxi,China)

机构地区：[1]陕西科技大学化学与化工学院,陕西省轻化工助剂重点实验室,陕西西安710021 [2]陕西科技大学前沿科学与技术转移研究院,陕西西安710021

出　　处：《精细石油化工》2020年第5期19-25,共7页Speciality Petrochemicals

基　　金：国家自然科学基金项目(No.21706152);陕西省自然科学基础研究计划(面上)项目(No.2018JM7046);陕西省教育厅专项(No.18JK0954)。

摘　　要：以2-氨基-5-取代苯基-1,3,4-噁二唑和α-溴代取代苯乙酮为原料,无水乙醇为溶剂,微波法合成了35种含芳基咪唑并[2,1-b]-1,3,4-噁二唑化合物,反应时间20 min,产率最高可达75%。目标化合物的结构均经IR、1H NMR、元素分析得以表征。与传统液相合成法相比,微波合成法具有操作简便、所需实验设备简单、反应时间短、产率较高、绿色环保等优点。A series of aryl imidazole[2,1-b]-1,3,4-oxadiazole were synthesized by microwave-assistant method,with the reaction of 2-amino-5-substituted-phenyl-1,3,4-oxadiazole andα-bromo acetophenone,the reaction time was 20 min,the yield was up to 75%.The structures were characterized by IR,1H NMR and elemental analysis.Comparied with conventional method,microwave synthesis method is simpler procedure,simpler equipment,fast,higher yields,environmentally green and so on.

关 键 词：2-氨基-5-取代苯基-1 3 4-噁二唑 α-溴代取代苯乙酮 咪唑并2 1-b-1 3 4-噁二唑 微波辅助 绿色合成 

分 类 号：TQ252.3[化学工程—有机化工]