口腔微生物种群与阿尔茨海默病关系的新进展  

New advances in the relationship between oral microbiota and Alzheimer’s disease

作　　者：李晶卉 张巍[2] LI Jing-hui;ZHANG Wei(Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing,100070,China)

机构地区：[1]首都医科大学附属北京天坛医院神经病学中心,北京100070 [2]首都医科大学附属北京天坛医院神经病学中心认知障碍性疾病科,北京100070

出　　处：《阿尔茨海默病及相关病杂志》2020年第3期204-209,共6页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项(2016YFC1306300,2016YFC1306000);国家重点研发计划-欧盟地平线2020计划合作项目(2017YFE0118800-779238);国家自然科学基金面上项目(81970992,81571229,81071015,30770745);北京市教育委员会科技发展计划重点项目(KZ-201610025030);北京市自然科学基金重点项目(4161004);北京市自然科学基金面上项目(7082032);北京市中医药科技发展资金项目(JJ2018-48)。

摘　　要：阿尔茨海默病(AD)是老年人群最常见的神经变性疾病和痴呆类型之一,但是,AD的病因与发病机制十分复杂,尚未完全阐明。口腔微生物种群包括细菌、病毒、真菌及螺旋体等,其可在老年群体中引发多种口腔疾病和全身性疾病。越来越多的研究证据表明,口腔微生物种群与AD关系密切。本文将介绍口腔微生物种群与AD相关的新进展,包括与AD相关的口腔微生物种群、口腔微生物种群入脑途径、口腔微生物种群与AD相关的机制以及靶向口腔微生物种群的综合管理。Alzheimer’s disease(AD)is one of the most common neurodegenerative diseases and types of dementia in the elderly population.However,the etiology and pathogenesis of AD are very complex and have not been fully elucidated.The oral microbiota includes bacteria,viruses,fungi and spirochetes etc.,which can cause various oral diseases and systemic diseases in the elderly population.Increasing research evidence suggests a close association between oral microbiota and AD.Here,we will introduce new advances in oral microbiota and AD,including the oral microbiota related to AD,the pathways of oral microbiota into the brain,the mechanisms underlying the correlation between oral microbiota and AD,and comprehensive management by targeting oral microbiota.

关 键 词：口腔微生物种群 阿尔茨海默病 新进展 

分 类 号：R749.16[医药卫生—神经病学与精神病学]