超敏肌钙蛋白I和肌酸激酶同工酶联合检测对AMI诊断的价值分析  

The Value of Combined Detection of High Sensitive TroponinⅠand Creatine Kinase Isoenzyme in the Diagnosis of AMI

作　　者：李海波 LI Haibo(Wuchuan People’s Hospital,Wuchuan 524500,China)

机构地区：[1]吴川市人民医院,广东吴川524500

出　　处：《中外医学研究》2020年第26期81-83,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究超敏肌钙蛋白I(hs-TnI)和肌酸激酶同工酶(CK-MB)联合检测对急性心肌梗死(AMI)的诊断价值。方法:选择2019年1-12月于笔者所在医院就诊的AMI患者100例作为研究组,同期100例健康体检者作为对照组,采用化学方法光对研究对象进行hs-TnI和CK-MB检测,比较两组上述检测指标的差异及hs-TnI和CK-MB联合检测对AMI的诊断价值。结果:研究组各时间段hs-TnI和CK-MB水平均高于对照组,差异均有统计学意义(P<0.05)。研究组hs-TnI水平于心肌梗死后1~6 h开始升高,13~24 h达到高峰,2~3 d后逐渐下降,但依然维持在较高水平;CK-MB水平于心肌梗死后1~6 h开始升高,13~24 h达到高峰,2~3 d后水平可达正常参考区间。hs-TnI升高窗口期长于CK-MB。研究组1~6 h、7~12 h、13~24 h、2~3 d hs-TnI阳性率分别为92.0%、97.0%、99.0%、77.0%,窗口期长;上述不同阶段CK-MB阳性率分别为25.0%、57.0%、85.0%、12.0%,窗口期短。二者联合诊断AMI的敏感度为85.0%,特异度为99.0%。结论:AMI后hs-TnI和CK-MB明显升高,二者联合检测对AMI的诊断具有重要意义。Objective:To explore the diagnostic value of high sensitive troponin I(hs-TnI)and creatine kinase isoenzyme(CK-MB)in acute myocardial infarction(AMI).Method:From January 2019 to December 2019,100 AMI patients in our hospital were selected as the study group and 100 healthy people were selected as the control group.The quality of hs-TnI and CK-MB were detected by chemical method light.The difference of the above detection indexes between the two groups and the diagnostic value of hs-TnI and CK-MB quality combined detection were compared.Result:The levels of hs-TnI and CK-MB in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).The hs-TnI level in the study group began to increase at 1-6 h after myocardial infarction,reached a peak at 13-24 h,and gradually decreased at 2-3 d,but still remained at a high level.The level of CK-MB began to rise at 1-6 h after AMI,reached a peak at 13-24 h,and reached a normal reference range at 2-3 days.The window period of hs-TnI elevation was longer than that of CK-MB.The positive rate of hs-TnI at 1-6 h,7-12 h,13-24 h,2-3 d in the study group were 92.0%,97.0%,99.0%,77.0%,with long window period,the positive rate of CK-MB at the same stages were 25.0%,57.0%,85.0%and 12.0%,respectively,with short window period.The sensitivity and specificity of hs-TnI positive rate were 85.0%and 99.0%respectively.Conclusion:hs-TnI and CK-MB are significantly increased after AMI.The combined detection of hs-TnI and CK-MB is of great significance for the diagnosis of AMI.

关 键 词：超敏肌钙蛋白Ⅰ 肌酸激酶同工酶 急性心肌梗死 诊断 

分 类 号：R542.22[医药卫生—心血管疾病]