热敏灸治疗冠心病失眠的疗效及对血清褪黑素、瘦素的影响  

Therapeutic Efficacy of Heat-sensitive Moxibustion for Insomnia in Coronary Heart Disease and Its Effects on Serum Melatonin and Leptin

作　　者：董庆[1] 徐复娟[1] 樊小平[1] DONG Qing;XU Fu-juan;FAN Xiao-ping(Zhejiang Changshan People’s Hospital,Zhejiang 324200,China)

机构地区：[1]浙江省常山县人民医院,浙江324200

出　　处：《上海针灸杂志》2020年第10期1235-1239,共5页Shanghai Journal of Acupuncture and Moxibustion

摘　　要：目的观察热敏灸治疗冠心病失眠的疗效及对血清褪黑素、瘦素的影响。方法将68例患者随机分为对照组、观察组,每组34例。两组均予冠心病常规西药治疗,对照组另予艾司唑仑治疗,观察组另予热敏灸治疗,治疗1个月。治疗前后观察心绞痛发作频次、持续时间,评定匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)评分,进行多导睡眠图监测,测定血清褪黑素、瘦素水平。治疗后判定疗效。结果观察组总有效率高于对照组(P<0.05);两组治疗后心绞痛发作频次及持续时间均降低(P<0.05),观察组心绞痛发作频次及持续时间低于对照组(P<0.05);两组治疗后PSQI评分均降低(P<0.05),观察组PSQI评分低于对照组(P<0.05);两组治疗后总睡眠时间增长(P<0.05),睡眠潜伏期、觉醒次数减少(P<0.05),观察组总睡眠时间、睡眠潜伏期及觉醒次数均优于对照组(P<0.05);观察组治疗后血清褪黑素水平升高(P<0.05),且高于对照组(P<0.05),其血清瘦素水平降低(P<0.05),且低于对照组(P<0.05)。结论在冠心病常规西药治疗基础上,热敏灸治疗冠心病失眠疗效确切,可有效缓解冠心病心绞痛症状,改善失眠症状,这可能与其调节患者血清褪黑素、瘦素水平有关。Objective To observe the therapeutic efficacy of heat-sensitive moxibustion for insomnia in coronary heart disease(CHD)and its effects on serum melatonin and leptin.Method Sixty-eight patients were randomized into a control group and an observation group,with 34 cases in each group.The two groups were both given conventional Western medication.In addition,the control group was given Estazolam and the observation group was given heat-sensitive moxibustion,lasting for 1 month.Before and after treatment,the angina flare-up times and duration were observed,Pittsburgh Sleep Quality Index(PSQI)was scored,polysomnogram was monitored and serum melatonin and leptin levels were detected.The therapeutic efficacy was evaluated after treatment.Result The total effective rate was higher in the observation group than in the control group(P<0.05);the angina flare-up times and duration dropped after treatment in both groups(P<0.05),and were lower in the observation group than in the control group(P<0.05);the PSQI score dropped after treatment in both groups(P<0.05),and was lower in the observation group than in the control group(P<0.05);the total sleep duration increased(P<0.05)and sleep latency and awakening times decreased(P<0.05)after treatment in the two groups,and the observation group was superior to the control group comparing the total sleep duration,sleep latency and awakening times(P<0.05);the serum melatonin level increased after treatment in the observation group(P<0.05)and was higher than that in the control group(P<0.05);the serum leptin level declined after treatment in the observation group(P<0.05)and was lower than that in the control group(P<0.05).Conclusion Based on the conventional Western medication for CHD,heat-sensitive moxibustion is effective for insomnia in CHD.It can effectively mitigate the angina symptom in CHD and insomnia symptoms,which may be associated with its regulation of the serum levels of melatonin and leptin.

关 键 词：艾条灸 热敏灸 冠心病 失眠症 褪黑素 瘦素 匹兹堡睡眠质量指数 

分 类 号：R246.1[医药卫生—针灸推拿学]