转基因作物非预期效应的代谢组学研究进展  

Advances in Metabolomics of Unintended Effects of Genetically Modified Crops

作　　者：刘慧玲 罗小伟 郭佳乐 张可炜[1] LIU Hui-ling;LUO Xiao-wei;GUO Jia-le;ZHANG Ke-wei(The Key Laboratory of Plant Development and Environmental Adaptation Biology,Ministry of Education,School of Life Sciences,Shandong University,Qingdao 266237,China)

机构地区：[1]山东大学生命科学学院植物发育与环境适应生物学教育部重点实验室,山东青岛266237

出　　处：《食品与药品》2020年第5期J0003-J0009,共7页Food and Drug

基　　金：转基因生物新品种培育科技重大专项──转基因耐旱耐盐碱棉花新品种培育(2016ZX08005-004)。

摘　　要：应用代谢组学方法分析转基因作物的化学组分,有望获得更多的植物细胞内化学成分数据信息,这些数据信息有助于评价转基因作物是否由于遗传转化而导致了非预期效应的发生,或转基因作物与来源亲本间不存在显著的差异,即是否具有实质等同性。本文介绍了转基因作物安全评价的一般性原则、非预期效应的概念、成因及代谢组学在转基因作物的非预期效应评估中的应用,旨在为转基因作物的安全性评估提供参考。The application of metabolomics to analyze the chemical composition of genetically modified(GM)crops is expected to obtain more information of chemical composition in plant cells.These data information will help to evaluate whether GM crops leads to the occurrence of unexpected effects,or whether the GM crop is substantially equivalent to the source parent.In addition,this paper introduces the general principles of safety assessment of GM crops,the concept and causes of unexpected effects,and the application of metabolomics in the evaluation of unexpected effects of GM crops,so as to provide reference for the safety assessment of GM crops.

关 键 词：转基因作物 非预期效应 代谢组学 实质等同性 

分 类 号：Q812[生物学—生物工程]