2012-2018年蒙自市不同人群乙肝五项标志物结果分析  

Analysis of five markers of hepatitis B in different populations in Mengzi city

作　　者：马秀秀 景正朝 吕继荣 卢波 郑英 王益民 MA Xiu-xiu;JING Zheng-chao;LVJi-rong;LU Bo;ZHENG Ying;WANG Yi-min(Institute of Nutrition and Food Hygiene,School of Public Health,Lanzhou University,Lanzhou,Gansu 730000,China;不详)

机构地区：[1]兰州大学公共卫生学院营养与食品卫生学研究所,甘肃兰州730000 [2]蒙自市疾病预防控制中心检验科,云南蒙自661100

出　　处：《现代预防医学》2020年第18期3430-3433,3452,共5页Modern Preventive Medicine

摘　　要：目的了解蒙自市不同人群乙肝感染现状,为当地乙肝防治工作提供依据。方法采用乳胶法进行乙肝病毒血清学检测,收集2012年1月1日-2018年12月31日蒙自市乙肝五项标志物的检测结果并对HBsAg阳性、单HBsAb阳性和五项全阴等指标进行统计学分析。结果 11 160例检测人群HBsAg阳性率为2.63%。2012-2018年HBsAg阳性率总体呈下降趋势。男性HBsAg阳性率高于女性,差异有统计学意义(χ~2=3.88,P<0.05)。45~54岁年龄组的HBsAg阳性率最高,其次为35~44岁年龄组。HBsAg携带主要模式中,以常见模式:(HBsAg+HBcAb)阳性、(HBsAg+HBeAb+HBc Ab)阳性(小三阳)和(HBsAg+HBeAg+HBcAb)阳性(大三阳)为主,共占乙肝感染人群的71.33%。检测人群单HBsAb阳性率较低(30.58%),其中0~4岁年龄组最低,为27.76%。五项阴性率较高(65.62%),其中0~4岁年龄组最高,为73.52%。结论蒙自市今后应将男性群体作为重点人群,并关注儿童和青壮年,同时要侧重大三阳模式、小三阳模式和全阴模式的人群。针对这些重点人群做好三级预防,早期宣传乙肝防护知识及其注射疫苗的必要性、早期诊断感染者防止肝脏进一步损坏、早期对乙肝患者进行抗病毒药物治疗。Objective The aim of this study was to understand the situation of HBV infection in different populations in Mengzi city,so as to provide the basis for the prevention and treatment of HBV.Methods The serological detection of hepatitis B virus was carried out by emulsion technique.The results of five hepatitis B markers in Mengzi city from January 1st 2012 to December 31st 2018 were collected,and the HBsAg positive,single HBsAb positive and five all negative indexes were statistically analyzed.Results The positive rate of HBsAg in 11160 cases was 2.63%.The positive rate of HBsAg from 2012 to 2018 showed a downward trend.The positive rate of HBsAg in male was significantly higher than that in female(χ2=3.88,P<0.05).The HBsAg positive rate was the highest in the 45-54 age group and the second high in the 35-44 age group.Among the main modes of HBsAg carrying,the common modes were:HBsAg+HBcAb positive,HBsAg+HBeAb+HBcAb positive(small three Yang)and HBsAg+HBeAg+HBcAb positive(big three Yang),accounting for 71.33%of the total HBV infected population.The positive rate of single HBsAb was lower(30.58%),and the lowest was in the 0-4 age group(27.76%).The negative rate of five items was higher(65.62%),and the highest was in the 0-4 age group(73.52%).Conclusion In the future,Mengzi city should take the male group as the key group,pay attention to children and young adults,and at the same time,focus on the major three Yang pattern,the small small three Yang and the all Yin pattern.We should do tertiary prevention for these key groups,publicize the knowledge of hepatitis B protection and the necessity of vaccination in the early stage,diagnose the infected persons in the early stage to prevent further liver damage,and treat hepatitis B patients with antiviral drugs in the early stage.

关 键 词：乙型肝炎 乙肝五项 模式 

分 类 号：R181.3[医药卫生—流行病学]