打箭菊化学成分研究  

Study on the chemical constituents from Pyrethrum tatsienense

作　　者：陈玉[1] 杜艳 滕海达 年贺凤 卢青秀 杨光忠[2] CHEN Yu;DU Yan;TENG Haida;NIAN Hefeng;LU Qingxiu;YANG Guangzhong(College of Chemistry and Materials Sciences,South-Central University for Nationalities,Wuhan 430074,China;School of Pharmacy,South-Central University for Nationalities,Wuhan 430074,China)

机构地区：[1]中南民族大学化学与材料科学学院,武汉430074 [2]中南民族大学药学院,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2020年第5期483-487,共5页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：国家重大新药创制科技重大专项(2017Z09301060)。

摘　　要：为研究打箭菊Pyrethrum tatsienense的化学成分,采用溶剂提取法、正反相硅胶柱色谱及高效液相色谱等多种色谱技术对其化学成分进行分离纯化.根据化合物的理化性质和波谱数据,从打箭菊70%乙醇提取物中分离得到的17个化合物,其结构分别鉴定为苜蓿素(1)、芹菜素(2)、木犀草素(3)、7-羟基香豆素(4)、异莨菪亭(5)、二氢松柏醇(6)、反式阿魏酸(7)、2-羟基苯丙醇(8)、对羟基苯甲醛(9)、对羟基苯乙酮(10)、对羟基苯甲酸(11)、3-甲氧基-4-羟基苯甲酸(12)、(rel-1R,2S,5R,6S)-2-(4-hydroxy-3-methoxyphenyl)-6-(3,4-methylenedioxyphenyl)-3,7-dioxabicyclo[3.3.0]octane(13)、(rel-1R,5R,6S)-6-(4-hydroxy-3-methoxyphenyl)-3,7-dioxabicyclo[3.3.0]octan-2-one(14)、3-吲哚甲醛(15)、(rel-3S,5R,6S,7E)-3,5,6-trihydroxy-7-megastigmen-9-one(16)、黑麦草内酯(17).化合物4~17均为首次从该植物中分离得到.To study the chemical constituents of Pyrethrum tatsienense,the chemical constituents were isolated and purified by solvent extraction method,the normal and reverse phase silica gel column chromatography and semi-preparative high performance liquid chromatography.The structures of all isolated compounds were identified on the basis of physicochemical properties and spectroscopic analysis,as well as comparisons with the data in literature.Seventeen compounds were isolated and elucidated as tricin(1),apigenin(2),luteolin(3),7-hydroxycoumarin(4),isoscopoletin(5),dihydroconiferylalcohol(6),trans-ferulic acid(7),2-hydroxyphenylpro-panol(8),4-hydroxybenzaldehyde(9),4-hydroxyacetophenone(10),4-hydroxybenzoicacid(11),3-methoxy-4-hydroxybenzoic acid(12),(rel-1R,2S,5R,6S)-2-(4-hydroxy-3-methoxyphenyl)-6-(3,4-methylenedioxyphenyl)-3,7-dioxa-bicyclo[3.3.0]octane(13),(rel-1R,5R,6S)-6-(4-hydroxy-3-methoxyphenyl)-3,7-dioxabicyclo[3.3.0]octan-2-one(14),indole-3-carbaldehyde(15),(rel-3S,5R,6S,7E)-3,5,6-trihydroxy-7-megastigmen-9-one(16),loliolide(17).Compounds 4-17 are isolated from this plant for the first time.

关 键 词：打箭菊 化学成分 香豆素 提取分离 

分 类 号：O657.61[理学—分析化学]