血清FGF21水平与老年冠心病患者肥胖、糖脂代谢和冠状动脉狭窄程度的相关性分析  

Correlation between serum FGF21 level and obesity,glycolipid metabolism and coronary stenosis in elderly patients with coronary heart disease

作　　者：徐红新[1,2,3] 周易[1,2,3] 刘畅 Xu Hongxin;Zhou Yi;Liu Chang(Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,China;不详)

机构地区：[1]武汉大学人民医院心血管内科,武汉430060 [2]武汉大学心血管病研究所,武汉430060 [3]心血管病湖北省重点实验室,武汉430060

出　　处：《中国循证心血管医学杂志》2020年第9期1091-1093,1097,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：湖北省自然科学基金(2018CFB752)。

摘　　要：目的探讨血清成纤维细胞生长因子(FGF21)在老年冠状动脉粥样硬化心脏病(冠心病)患者中的表达水平,及其与肥胖、糖脂代谢和冠状动脉(冠脉)狭窄程度之间的关系。方法纳入老年冠心病患者38例(试验组),选取同期冠脉造影正常的老年患者42例(对照组)。收集两组患者的一般临床资料;检测空腹血糖、脂代谢指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)];酶联免疫吸附法检测所有患者血清FGF21水平;运用Gensini评分量化试验组患者的冠脉狭窄程度;采用Pearson分析探讨老年冠心病患者血清FGF21水平与肥胖、糖脂代谢指标、冠脉狭窄程度之间的相关性。结果两组患者在年龄、性别方面差异无统计学意义(P>0.05)。试验组患者的体质指数(BMI)、腰臀比、空腹血糖、TC、TG和LDL-C显著高于对照组,差异具有统计学意义(P<0.05)。与对照组相比较,试验组血清FGF21水平显著升高,差异具有统计学意义(P<0.05)。相关性结果显示,老年冠心病患者血清FGF21水平与BMI、腰臀比、空腹血糖、TC、TG、LDL-C、Gensini评分呈正相关,相关系数r分别为0.573、0.495、0.614、0.426、0.271、0.380和0.689,差异具有统计学意义(P<0.05)。结论血清FGF21在老年冠心病患者中的表达显著升高,且与肥胖、高血糖、高血脂和冠脉狭窄程度密切相关。Objective To investigate the expression level of serum fibroblast growth factor 21(FGF21)in elderly patients with coronary atherosclerotic heart disease(coronary heart disease,CHD)and its relationship with obesity,glycolipid metabolism and coronary artery stenosis.Methods A total of 38 elderly patients with CHD(test group)were enrolled,and 42 elderly patients with normal coronary angiography were selected(control group).General clinical data of two groups of patients was collected.Fasting blood glucose,lipid metabolism indicators including total cholesterol,triglycerides,low-density lipoprotein cholesterol and high-density lipoprotein cholesterol)were all detected.Enzymelinked immunosorbent assay was applied to detect serum FGF21 level in all patients.The Gensini score was used to quantify the degree of coronary stenosis in the test group.Pearson analysis was used to investigate the correlation between serum FGF21 level and obesity,glucose and lipid metabolism index,and coronary stenosis in elderly patients with CHD.Results There was no significant difference in age and gender between the two groups(P>0.05).Body mass index,waist-to-hip ratio,fasting blood glucose,total cholesterol,triglyceride and low-density lipoprotein cholesterol were significantly higher in the test group than in the control group,their difference was statistically significant(P<0.05).Compared with the control group,the serum FGF21 level was significantly increased in the test group,their difference was statistically significant(P<0.05).Correlation results showed that serum FGF21 level in elderly patients with CHD were positively correlated with body mass index,waist-to-hip ratio,fasting blood glucose,total cholesterol,triglyceride,low-density lipoprotein cholesterol,and Gensini score.And the correlation coefficients r was 0.573,0.495,0.614,0.426,0.271,0.380,and 0.689,respectively(P<0.05).Conclusion The expression of serum FGF21 is significantly increased in elderly patients with coronary heart disease,which is closely related to obesity,hype

关 键 词：成纤维细胞生长因子21 老年冠心病 肥胖 糖脂代谢 冠脉狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]