阻塞性睡眠呼吸暂停低通气综合征上气道壁顺应性改变研究进展  

Research progress of upper airway wall compliance in obstructive sleep apnea hypopnea syndrome

作　　者：金峰 何建乔 苏英锋[1] Jin Feng;He Jianqiao;Su Yingfeng(Department of Otolaryngology,the Second Affiliated Hospital of Dalian Medical University,Dalian 116023,China)

机构地区：[1]大连医科大学附属第二医院耳鼻咽喉科,116023

出　　处：《国际耳鼻咽喉头颈外科杂志》2020年第5期274-278,共5页International Journal of Otolaryngology-Head and Neck Surgery

基　　金：大连市科技惠民计划(2019J13SN118)。

摘　　要：阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是睡眠呼吸暂停综合征中最常见的一种临床亚型,可累及多系统并造成多器官损害,其发病机制较为复杂,一直是国内外研究的热点。OSAHS患者上气道顺应性改变在其发病机制研究、临床治疗方案的选择和疗效评估方面的研究中均为主要因素。上气道肌肉的结构和功能状态直接决定了上气道顺应性的正常与否,相关的研究涉及肌纤维的组织学研究及神经电生理等方面。近年来,生物力学研究方法在上气道顺应性改变的研究中也扮演了重要角色,本文对上述研究进展做一综述。Obstructive sleep apnea hypopnea syn drome(OSAHS)is one of the most common clinical subtypes of sleep apnea syndrome,which can involve multiple systems and cause multiple organ damage.Its pathogenesis is complex,and it is a hot spot of research at home and abroad.The changes of upper airway compliance in patients with OSAHS are the main factors in the study of pathogenesis,selection of clinical treatment plan and evaluation of curative effect.The structure and fbnction of the upper airway muscles directly detennine whether the upper airway compliance is normal or not.The related research involves the histological research of muscle fibers and neuroelectrophysiology.In recent years,biomechanical research methods also play an important role in the research of the upper airway complianee changes.This paper reviews the research progress of the above aspects.

关 键 词：睡眠呼吸暂停 阻塞性 顺应性 生物力学 组织学 电生理学 

分 类 号：R766[医药卫生—耳鼻咽喉科]