宁夏定点医院新型冠状病毒肺炎患者炎症指标变化的相关性因素分析  

Analysis on correlation factors of changes of inflammatory indicators in patients with coronavirus disease 2019 in Ningxia designated hospitals

作　　者：魏建华 陆敬儒 郭蕾 徐麟 伍魏 张伟杰 刘伯飞 张瑞卿 曹相原[2] 谢峰[2] Wei Jianhua;Lu Jingru;Guo Lei;Xu Lin;Wu Wei;Zhang Weijie;Liu Bofei;Zhang Ruiqing;Cao Xiangyuan;Xie Feng(The Fourth People's Hospital of Ningxia Hui Auonomous Region,Yinchuan 750021,Ningxia Hui Autonomous Region,China;General Hospilal of Ningxia Medical University,Yinchuan 750004,Ningxia Hui Autonomous Region,China)

机构地区：[1]宁夏回族自治区第四人民医院,宁夏回族自治区银川750021 [2]宁夏医科大学总医院,宁夏回族自治区银川750004

出　　处：《中国中西医结合急救杂志》2020年第5期540-542,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：宁夏回族自治区重点研发计划科技支撑项目(2020BEG01003)。

摘　　要：目的 观察新型冠状病毒肺炎(简称新冠肺炎)患者炎症指标的变化,并探讨其与相关性因素之间的关系.方法 采用回顾性研究方法.收集2020年1月24日至2月25日入住宁夏回族自治区第四人民医院的71例新冠肺炎患者的临床资料,分析并比较不同临床分型、性别及年龄患者之间白细胞计数(WBC)、中性粒细胞计数(NEU)、淋巴细胞计数(LYM)、红细胞沉降率(ESR)、超敏C-反应蛋白(hs-CRP)和降钙素原(PCT)的差异.结果 ①不同临床分型中,轻型、普通型患者各项炎症指标基本正常;重型及危重型患者WBC、NEU、LYM均明显降低,分别为(3.13±1.27)×10^9/L、(0.93±0.39)×10^9/L、(0.85±0.45)×10^9/L.病情越重,细胞数降低越明显,重型及危重型组WBC、NEU、LYM明显低于普通型组和轻型组〔WBC(×10^9/L):3.13±1.27比4.83±1.46、6.53±2.39,NEU(×10^9/L):0.93±0.39比2.82±1.26、3.90±1.80,LYM(×10^9/L):0.85±0.45比1.59±0.62、1.99±0.77,均P<0.05〕.轻型组患者ESR、hs-CRP及PCT均在正常参考值范围;普通型组患者ESR、hs-CRP升高,重型及危重型组患者ESR、hs-CRP及PCT均升高,且病情越重,ESR、hs-CRP及PCT升高越明显,重型及危重型组ESR、hs-CRP及PCT高于普通型组和轻型组〔ESR(mm/1h):17.1(26.2)比6.5(17.0)、1.0(4.5),hs-CRP(mg/L):24.69(28.89)比4.07(9.72)、0.51(2.76),PCT(μg/L):0.130(0.090)比0.052(0.260)、0.036(0.040)〕.②不同性别患者各项炎症指标比较差异均无统计学意义(均P>0.05).③年龄因素中,不同年龄组LYM、ESR、hs-CRP比较差异均有统计学意义(均P<0.05).随年龄增长,WBC和LYM呈先下降后升高的趋势,以50-65岁组最低〔分别为(4.90±1.65)×10^9/L和(1.22±0.41)×10^9/L〕;NEU逐渐升高,以>65岁组最高〔(3.43±1.80)×10^9/L〕;ESR、hs-CRP和PCT均呈先升高后降低的趋势,以50-65岁组最高〔分别为19.50(39.00)mm/1h、18.00(44.13)mg/L、0.08(0.09)μg/L〕.结论 新冠肺炎患者炎症指标的变化与病情严重程度有一定的关系,这�Objective To observe the changes of inflammatory indexes in patients with coronavirus disease 2019(COVID-19)and approach their correlated factors.Methods Using retrospective study method,the elinical data of 71 patients admitted to the Fourth People's Hospital of Ningxia Hui Aulonomous Region from January 24 to February 25,2020 were ollected.The diferences in white blood cell count(WBC),neutrophil count(NEU),lymphocyte count(LYM),erythrocyte sedimentation rate(ESR),hypersensitive C-reactive protein(hs-CRP)and procaleitonin(PCT)among patients with different clinical types,genders and ages were analyzed and compared.Results①In different clinical types,the various inflammatory indexes of mild and ordinary patients were basically normal;WBC,NEU and LYM in severe and critical patients deereased significanly,which were(3.13±1.27)×10^9/L,(0.93±0.38)×10^9/L,and(0.85±0.45)×10^9/L,respectively.The more severe the disease,the more significant the decrease in cell number,and WBC,NEU and LYM in severe and critical groups were significantly lower than those in ordinary and mild groups[WBC(×10^9/L):3.13±1.27 vs.4.83±1.46,6.53±2.39,NEU(×10^9/L);0.93±0.39vs.2.82±1.26,3.90±1.80,LYM(×10^9/L):0.85+0.45 vs.1.59±0.62,1.99+0.77,all P<0.05].ESR,hs-CRP and PCT of mild group were all within normal reference range;ESR,hs-CRP and PCT in ordinary group were increased;ESR,hs-CRP and PCT in severe and critical groups were also increased,and the more serious the disease,the higher the ESR,hs-CRP and PCT;ESR.hs-CRP and PCT in severe and critical groups were higher than those in mild and ordinary groups[ESR(mm/lh):17.1(26.2)vs.6.5(17.0),1.0(4.5),hs-CRP(mg/L):24.69(28.89)vs.4.07(9.72).0.51(2.76),PCT(μg/L):0.130(0.090)vs.0.052(0.260),0.036(0.040)].②There was no significant diference in inflammatory indexes between dffrent genders(all P>0.05).③Among age factors,the diferences in LYM,ESR and hs-CRP among different age groups were statistically significant(all P<0.05).With increase of age,WBC and LYM decreased first and then inc

关 键 词：新型冠状病毒肺炎 炎症指标 规范监测 

分 类 号：R54[医药卫生—心血管疾病]