临床分析:强直性脊柱炎患者的血脂谱及其与疾病活动关系  

Clinical Analysis of Lipid Profile and Its Relationship with Disease Activity in Patients with Ankylosing Spondylitis

作　　者：贺汝燕[1] 饶咏梅[1] HE Ru-yan;RAO Yong-mei(Xuzhou Central Hospital,Xuzhou,Jiangsu,221009,China)

机构地区：[1]徐州市中心医院风湿科,江苏徐州221009

出　　处：《中国血液流变学杂志》2020年第1期64-66,共3页Chinese Journal of Hemorheology

摘　　要：目的 研究强直性脊柱炎患者的血脂谱特点及其与疾病活动的关系.方法 比较强直性脊柱炎与健康体检者的血脂谱、活动期与稳定期患者的血脂谱,并分析其与疾病活动的关系.结果 与健康体检者比,强直性脊柱炎患者的总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)减低,年龄大,差异有统计学意义(P=0.0300,P<0.0001,P=0.0191);低密度脂蛋白胆固醇(LDL-C)、身体质量指数(BMI)、性别比差异无统计学意义(P>0.05).强直性脊柱炎活动组与稳定组相比,脂蛋白a(LP(a))、血沉(ESR)、C反应蛋白(CRP)增高(P=0.0059,P<0.0001,P=0.0005),TC、TG、HDL-C、LDL-C、载脂蛋白AⅠ(apoA-Ⅰ)、载脂蛋白B(apoB)、BMI差异无统计学意义(P>0.05).LP(a)与疾病活动有秩相关关系(rs=0.33228,P=0.0362);Logistic回归分析示LP(a)对疾病活动的影响差异无统计学意义(回归系数β=0.00373,OR=1.004,95%CI:0.997~1.011,P=0.2955).结论 强直性脊柱炎患者的TC、HDL-C水平低,活动期的强直性脊柱炎患者LP(a)、ESR、CRP值增高,LP(a)与强直性脊柱炎疾病活动存在秩相关关系,但不能根据其数值推测疾病活动度.Objective To study lipid profile and its relationship with disease activity in patients with ankylosing spondylitis.Methods The lipid profiles of patients with ankylosing spondylitis were compared with those of healthy subjects,active patients and stable patients,and their relationship with disease activity was analyzed.Results Compared with healthy subjects,the patients with ankylosing spondylitis has lower total cholesterol(TC),lower high-density lipoprotein cholesterol(HDL-C),and the older age with statistical significance(P=0.0300,P<0.0001,P=0.0191),and no significant difference in low-density lipoprotein cholesterol(LDL-C),body mass index(BMI)and gender(P>0.05).Compared with the stable group,the activity group with ankylosing spondylitis has higher lipoprotein(a)(LP(a)),erythrocyte sedimentation rate(ESR),and C-reaction protein(CRP)(P=0.0059,P<0.0001,P=0.0005),no statistical difference in TC,TG,HDL-C,LDL-C,apolipoprotein a-I(apoA-I),apolipoprotein B(apoB)and BMI(P>0.05).LP(a)had rank correlation with disease activity(r=0.33228,P=0.0362).Logistic regression analysis showed that the influence of LP(a)on disease activity was not statistically significant(regression coefficient β=0.00373,OR=1.004,95%CI:0.997-1.011,P=0.2955).Conclusion The ankylosing spondylitis patients has lower TC,HLD-C,active phase of ankylosing spondylitis patients has higher LP(a),ESR,CRP value.LP(a)and ankylosing spondylitis disease activity has rank correlation,but can not predict disease activity degree according to its value.

关 键 词：强直性脊柱炎 血脂谱 疾病活动 临床分析 

分 类 号：R593.23[医药卫生—内科学]